Microbial Secondary Metabolites in Floor Dust of a Water Damaged Office Building

Details

• Personal Author:
  Cikalo J ; D'Angelo R ; Doney B ; Feeley T ; Martinez L ; Middendorf, Paul J. ; Miller, William E.
• Description:
  Objective: The objective was to characterize workplace toluene diisocyanate (TDI) exposures in U.S. TDI production plants using standardized industrial hygiene exposure assessment procedures for use in a prospective epidemiologic study of occupational asthma. Methods: A uniform exposure assessment strategy was developed by a team of industrial hygienists from the National Institute for Occupational Safety and Health (NIOSH) and from representatives of each participating plant who were knowledgeable of the plants processes and operations. To provide the exposure data needed to achieve the study's aims, the assessment strategy included: development of similar exposure groups, identification of high potential exposure tasks, quantitative and qualitative exposure assessment, and the utilization of standardized sampling and analytical methods. Air samples were collected with calibrated personal sampling pumps and analyzed using a method equivalent to the OSHA 42 Method for measuring airborne personal exposures to TDI. Results: A total of over 2600 samples were collected. 1594 representative routine full shift time-weighted average (TWA) and 755 routine short term high potential exposure task (HPET) air samples were collected among groups with similar job titles across three TDI plants over a nearly seven-year period. Data derived similar exposure groups (SEGs) were developed across the plants based on TWA sampling using cluster analysis. Individual cumulative exposure estimates were developed based on the cross-facility similar exposure groups. The arithmetic mean TWA exposure was 0.65 ppb. Without adjusting for the use of respirators, the highest TWA exposures occurred among field operators, TDI loading, and TDI drumming SEGs. Of the 1594 TWA routine samples, 35 were > 5 ppb and of the 755 HPET routine samples, 83 were > 20 ppb. Workplace routine TWA exposures to TDI were adequately characterized, but HPET exposures were inadequately sampled. Conclusions: The TDI exposure assessment of the primary producers of TDI in the U.S. was one of the most complete to date. The measured exposures can be used to support epidemiologic analysis of the relationship between exposures to TDI and asthma. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Environmental Monitoring Epidemiology Isocyanates Occupational Health Safety Workplace
• Keywords:
  Air Sampling Diisocyanates Exposure Assessment Occupational Asthma Workplace Studies
• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Georgia ; Louisiana ; Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Pennsylvania ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division ; OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  57-58
• NIOSHTIC Number:
  nn:20065996
• Citation:
  AIHce 2016: American Industrial Hygiene Conference and Exposition Pathways to Progress, May 21-26, 2016, Baltimore, Maryland. Falls Church, VA: American Industrial Hygiene Association, 2016 May; :57-58
• Contact Point Address:
  B. Doney, CDC/NIOSH, Morgantown, WV
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  False
• Source Full Name:
  AIHce 2016: American Industrial Hygiene Conference and Exposition Pathways to Progress, May 21-26, 2016, Baltimore, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:181107f087af0d8b8ce2ba5b795c1867118b22804935f0c101b1f2a40179e12f1f7b9fba7aa1c83600a719220513f520257ed74cd42e4201e8b675d4c3b1ad54
• Download URL:
  https://stacks.cdc.gov/view/cdc/209087/cdc_209087_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]