Particulate Matter and Alzheimer’s Disease: An Intimate Connection

Details

• Personal Author:
  Durisek GR III ; Escobar Y-NH ; Mackos AR ; O'Piela DR ; Wold LE ; Durisek GR III ; Escobar Y-NH ; Mackos AR ; O'Piela DR ; Wold LE
• Description:
  The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. Particulate matter (PM) includes various gases, liquids, and particles in suspension and is produced by industrial activities such as fossil fuel combustion and natural events including wildfires and volcanic eruptions. Although agencies have attempted to reduce acceptable airborne particulate levels, with urbanization and population growth, these policies have been only moderately effective in mitigating disease progression. A growing area of research is focused on the role of PM exposure in the progression of Alzheimer's disease (AD). This review will summarize the knowns and unknowns of this expanding field. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Hazardous Substances Occupational Health Particulate Matter Safety
• Keywords:
  Airborne Particulates Air Quality Brain Disorders Fossil Fuels Guidelines Liquefied Gases Natural Disasters Particulates Pathogenesis Toxins
• ISSN:
  1471-4914
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  28
• Issue:
  9
• NIOSHTIC Number:
  nn:20065949
• Citation:
  Trends Mol Med 2022 Sep; 28(9):770-780
• Contact Point Address:
  Loren E. Wold, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH
• Email:
  loren.wold@osumc.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20200701
• Source Full Name:
  Trends in Molecular Medicine
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19c511f56f4011769c28e6e7794b80cc39d5103590dd029efffe29f45f281cec8f9923a58ae28ceb42ac80152f4c0b222ad6c198a65a0636f6d401c607fbfc38
• Download URL:
  https://stacks.cdc.gov/view/cdc/209045/cdc_209045_DS1.pdf
• File Type:
  [PDF - 1.20 MB ]