Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA

Fiebelkorn, Amy Parker; Lawler, Jacqueline; Curns, Aaron T.; Brandeburg, Christina; Wallace, Gregory S.

doi:10.3201/eid1909.130299

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Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA

Published Date:

2013

Publisher's site:

http://dx.doi.org/10.3201/eid1909.130299 New Site Icon

Source:

Emerg Infect Dis. 19(9):1411-1417.

[PDF-543.62 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Fiebelkorn, Amy Parker ; Lawler, Jacqueline ; Curns, Aaron T. ; Brandeburg, Christina ; Wallace, Gregory S. ;

Description:

Although the measles-mumps-rubella (MMR) vaccine is not recommended for mumps postexposure prophylaxis (PEP), data on its effectiveness are limited. During the 2009-2010 mumps outbreak in the northeastern United States, we assessed effectiveness of PEP with a third dose of MMR vaccine among contacts in Orthodox Jewish households who were given a third dose within 5 days of mumps onset in the household's index patient. We compared mumps attack rates between persons who received a third MMR dose during the first incubation period after onset in the index patient and 2-dose vaccinated persons who had not. Twenty-eight (11.7%) of 239 eligible household members received a third MMR dose as PEP. Mumps attack rates were 0% among third-dose recipients versus 5.2% among 2-dose recipients without PEP (p=0.57). Although a third MMR dose administered as PEP did not have a significant effect, it may offer some benefits in specific outbreak contexts.

Subject:

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

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