Plasmodium falciparum Mutant Haplotype Infection during Pregnancy Associated with Reduced Birthweight, Tanzania

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Minja, Daniel T. R. ; Schmiegelow, Christentze ; Mmbando, Bruno ; Boström, Stéphanie ; Oesterholt, Mayke ; Magistrado, Pamela ; Pehrson, Caroline ; John, Davis ; Salanti, Ali ; Luty, Adrian J.F. ; Lemnge, Martha ; Theander, Thor ; Lusingu, John ; Alifrangis, Michael
• Description:
  Intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is a key strategy in the control of pregnancy-associated malaria. However, this strategy is compromised by widespread drug resistance from single-nucleotide polymorphisms in the Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthetase genes. During September 2008-October 2010, we monitored a cohort of 924 pregnant women in an area of Tanzania with declining malaria transmission. P. falciparum parasites were genotyped, and the effect of infecting haplotypes on birthweight was assessed. Of the genotyped parasites, 9.3%, 46.3%, and 44.4% had quadruple or less, quintuple, and sextuple mutated haplotypes, respectively. Mutant haplotypes were unrelated to SP doses. Compared with infections with the less-mutated haplotypes, infections with the sextuple haplotype mutation were associated with lower (359 g) birthweights. Continued use of the suboptimal IPTp-SP regimen should be reevaluated, and alternative strategies (e.g., intermittent screening and treatment or intermittent treatment with safe and effective alternative drugs) should be evaluated.
• Subjects:
  Adolescent Adult Alleles Female Gestational Age Haplotypes Humans Infant, Low Birth Weight Malaria, Falciparum Mutation Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications, Parasitic Pregnancy Outcome Prospective Studies Research Tetrahydrofolate Dehydrogenase Young Adult

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• Source:
  Emerg Infect Dis. 19(9):1446-1454.
• Document Type:
  Journal Article
• Place as Subject:
  Tanzania
• Location:
  Africa
• Volume:
  19
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:57720be6cd2e7f18653e8aaf0f62158c921a7d371cc176e8358580b52177f352
• Download URL:
  https://stacks.cdc.gov/view/cdc/20895/cdc_20895_DS1.pdf
• File Type:
  [PDF - 508.60 KB ]