U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Health Risk Assessment of Exposure to Organochlorine Pesticides in the General Population in Seoul, Korea over 12 Years: A Cross-Sectional Epidemiological Study



Details

  • Personal Author:
  • Description:
    This study evaluated the 12-year trends in serum levels of 28 organochlorine pesticides (OCPs) in 880 adults living in Seoul, Korea. The OCP levels decreased from 2006 to 2017, and p,p'-dichlorodiphenyldichloroethylene was a predominant compound. OCP levels were higher in females than in males, and showed positive associations with BMI and age. The OCP concentrations had inverted U-shaped associations with low-density lipoprotein cholesterol and total cholesterol. Concentrations of β-hexachlorocyclohexane were significantly higher in patients with hypertension than in participants that were normotensive. OCP levels showed positive associations with uric acid, creatinine, and thyroid-stimulating hormone, but negative associations with free thyroxine. Participants with diabetes had significantly higher OCP levels than those without it. Principal component analysis suggested possible differences in disease manifestation depending on the composition of OCPs. These results suggest that OCPs might disturb renal transport and thyroid homeostasis. To our knowledge, the inverted U-shaped associations of heptachlor epoxide and endosulfan with cholesterol, the epidemiological associations of trans-nonachlor and endosulfan with thyroid hormones, and the association of p,p'-DDE with hyperuricemia have not been previously reported in general population. This is the first long-term study to show trends of 28 OCPs in serum and associations with various health indicators in Korea. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0304-3894
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    424
  • NIOSHTIC Number:
    nn:20070723
  • Citation:
    J Hazard Mater 2022 Feb; 424(Pt B):127381
  • Contact Point Address:
    Yoon-Seok Chang, Division of Environmental Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
  • Email:
    yschang@postech.ac.kr
  • Federal Fiscal Year:
    2022
  • Performing Organization:
    University of Michigan, Ann Arbor
  • Peer Reviewed:
    True
  • Part Number:
    B
  • Start Date:
    20050701
  • Source Full Name:
    Journal of Hazardous Materials
  • End Date:
    20280630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:8bee17cc698958714aa9e1dea0da056222d37630c1b3e28d3b42eab93572123b7d4530484a3efd5c543bf9311805aef5ce6fe50e2e57293a3e9262b3b55851f1
  • Download URL:
  • File Type:
    Filetype[PDF - 2.49 MB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP