Association Between Toxic and Essential Metals in Blood and Global DNA Methylation Among Electronic Waste Workers in Agbogbloshie, Ghana

Details

• Personal Author:
  Agyekum TP ; Arko-Mensah J ; Basu N ; Batterman S ; Dwomoh D ; Fobil JN ; Issah I ; Robins TG ; Rozek LS ; Zarins KR
• Description:
  Aberrant global DNA methylation status is a known biomarker for increased disease risk, especially cancer. There is little published data on the association between toxic and essential metal mixtures and global DNA methylation in electronic waste (e-waste) workers. We aimed to establish the association between toxic and essential metals in blood and the effect of their interactions on global DNA methylation among e-waste recyclers and a reference group in Ghana. We used ICP-MS to measure the level of five metals (Se, Zn, Mn, Cd, and Pb) in the blood of 100 e-waste workers and 51 controls. We quantified blood DNA methylation levels of LINE-1 as an indicator of global DNA methylation. Cd, Mn, and Se levels were significantly higher in the reference group than in e-waste workers. Only Pb was significantly higher in the e-waste workers compared to the controls. Our linear regression analysis results showed a significant inverse association between Zn and LINE-1 DNA methylation (βZn = - 0.912; 95% CI, - 1.512, - 0.306; p = 0.003) which corresponds to a 0.009 decrease in %LINE-1 methylation (95% CI, - 0.015, - 0.003; p = 0.003) for a 1% increase in Zn concentration. Potential interactions between Cd and Zn on global DNA methylation were observed. In summary, co-exposure to toxic and essential metals is associated with global (LINE-1) DNA methylation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Electrical Equipment And Supplies Epidemiology Genetics Metals Occupational Health Particulate Matter Recycling Safety
• Keywords:
  Author Keywords: DNA Methylation DNA Damage E-waste Recyclers Electronic Devices Epigenetics Essential Metals Exposure Assessment LINE-1 Particulates Toxic Metals Waste Disposal

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• ISSN:
  0944-1344
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• Issue:
  48
• NIOSHTIC Number:
  nn:20070719
• Citation:
  Environ Sci Pollut Res 2022 Oct; 29(48):72946-72956
• Contact Point Address:
  Ibrahim Issah, Department of Biological, Environmental and Occupational Health Sciences, School of Public Health, University of Ghana, Accra, Ghana
• Email:
  ibrahimissah111@gmail.com
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science and Pollution Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:32c5a6edb5dd8a00c9a11f9794add33faf12e198745d9420d58c93e0ae5dd95596ed531f93ac47f39b97ef94d008afce2528d22f443da3664d537044ef5e928e
• Download URL:
  https://stacks.cdc.gov/view/cdc/208891/cdc_208891_DS1.pdf
• File Type:
  [PDF - 932.12 KB ]