Association Between Global DNA Methylation (LINE-1) and Occupational Particulate Matter Exposure Among Informal Electronic-Waste Recyclers in Ghana

Details

• Personal Author:
  Agyekum TP ; Arko-Mensah J ; Batterman S ; Dwumoh D ; Fobil JN ; Issah I ; Rentschler K ; Robins TG ; Rozek LS
• Description:
  This study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste workers serving as controls. Long interspersed nucleotide repetitive elements-1 (LINE-1) was measured by pyrosequencing. Personal PM2.5 and PM10 were measured over a 4-hour work-shift using real-time particulate monitors incorporated into a backpack. Linear regression models were used to assess the association between PM and LINE-1 DNA methylation. The concentrations of PM2.5 and PM10 were significantly higher among the e-waste workers than the controls (77.32 vs 34.88, p < 0.001 and 210.21 vs 121.92, p < 0.001, respectively). PM2.5 exposure was associated with increased LINE-1 CpG2 DNA methylation (β = 0.003; 95% CI; 0.001, 0.006; p = 0.022) but not with the average of all 4 CpG sites of LINE-1. In summary, high levels of PM2.5 exposure was associated with increased levels of global DNA methylation in a site-specific manner. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Electrical Equipment And Supplies Occupational Health Particulate Matter Recycling Safety
• Keywords:
  Air Pollutants Author Keywords: DNA Methylation DNA Damage E-waste E-waste Workers Electronic Devices Exposure Assessment LINE-1 Particle Size Particulates PM2.5 PM10 Waste Disposal

  More +
• ISSN:
  0960-3123
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  11
• NIOSHTIC Number:
  nn:20070718
• Citation:
  Int J Environ Health Res 2022 Nov; 32(11):2406-2424
• Contact Point Address:
  Ibrahim Issah, Department of Biological, Environmental and Occupational Health Sciences, University of Ghana, School of Public Health, Accra, Ghana
• Email:
  ibrahimissah111@gmail.com
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Environmental Health Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:97638781a1883bc6049d93b4f790a23b1bf2c790403f2d7bdbc1611a4fb4c9d12933a0b147e894aa4a0fb83b7184ba096573b42f4b531f0910c875ca21096a01
• Download URL:
  https://stacks.cdc.gov/view/cdc/208890/cdc_208890_DS1.pdf
• File Type:
  [PDF - 1.73 MB ]