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Pathogenesis and Inflammaging in Myelodysplastic Syndrome



Details

  • Personal Author:
  • Description:
    Myelodysplastic syndromes (MDS) are a genetically complex and phenotypically diverse set of clonal hematologic neoplasms that occur with increasing frequency with age. MDS has long been associated with systemic inflammatory conditions and disordered inflammatory signaling is implicated in MDS pathogenesis. A rise in sterile inflammation occurs with ageing and the term "inflammaging" has been coined by to describe this phenomenon. This distinct form of sterile inflammation has an unknown role in in the pathogenesis of myeloid malignancies despite shared correlations with age and ageing-related diseases. More recent is a discovery that many cases of MDS arise from clonal hematopoiesis of indeterminate potential (CHIP), an age associated, asymptomatic pre-disease state. The interrelationship between ageing, inflammation and clonal CHIP is complex and likely bidirectional with causality between inflammaging and CHIP potentially instrumental to understanding MDS pathogenesis. Here we review the concept of inflammaging and MDS pathogenesis and explore their causal relationship by introducing a novel framing mechanism of "pre-clonal inflammaging" and "clonal inflammaging". We aim to harmonize research on ageing, inflammation and MDS pathogenesis by contextualizing the current understanding of inflammaging and the ageing hematopoietic system with what is known about the etiology of MDS via its progression from CHIP. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1592-8721
  • Document Type:
    Text
  • Funding:
    Cooperative Agreement
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    283-299
  • Volume:
    110
  • Issue:
    2
  • NIOSHTIC Number:
    nn:20070703
  • Citation:
    Haematologica 2025 Feb; 110(2):283-299
  • Contact Point Address:
    Michael R. Savona, Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232
  • Email:
    Michael.savona@vumc.org
  • Federal Fiscal Year:
    2025
  • Performing Organization:
    Albert Einstein College of Medicine, Bronx, New York
  • Peer Reviewed:
    True
  • Start Date:
    20210701
  • Source Full Name:
    Haematologica
  • End Date:
    20240630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:43f160cef6abcc8b94ed5551e8045609012db60582e7a9d3ee244ee6f8ab2c613841d3fec23d069d66c7ec853e8e68dc3a71dc2c263a6c563d6f800248ec1772
  • Download URL:
  • File Type:
    Filetype[PDF - 1.65 MB ]
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