Prenatal Vitamin Intake in First Month of Pregnancy and DNA Methylation in Cord Blood and Placenta in Two Prospective Cohorts

Details

• Personal Author:
  Bakulski KM ; Benke KS ; Croen LA ; Dou JF ; Fallin D ; Feinberg JI ; Hertz-Picciotto I ; LaSalle JM ; Middleton LYM ; Newschaffer CJ ; Schmidt RJ ; Zhu Y
• Description:
  Background: Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, and vitamins A, B6, B12, and D, and usually they contain higher concentrations of folic acid and iron than regular multivitamins in the US Nutrient levels can impact epigenetic factors such as DNA methylation, but relationships between maternal prenatal vitamin use and DNA methylation have been relatively understudied. We examined use of prenatal vitamins in the first month of pregnancy in relation to cord blood and placenta DNA methylation in two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk Learning Early Signs (MARBLES) studies. Results: In placenta, prenatal vitamin intake was marginally associated with -0.52% (95% CI -1.04, 0.01) lower mean array-wide DNA methylation in EARLI, and associated with -0.60% (-1.08, -0.13) lower mean array-wide DNA methylation in MARBLES. There was little consistency in the associations between prenatal vitamin intake and single DNA methylation site effect estimates across cohorts and tissues, with only a few overlapping sites with correlated effect estimates. However, the single DNA methylation sites with p-value < 0.01 (EARLI cord nCpGs = 4068, EARLI placenta nCpGs = 3647, MARBLES cord nCpGs = 4068, MARBLES placenta nCpGs = 9563) were consistently enriched in neuronal developmental pathways. Conclusions: Together, our findings suggest that prenatal vitamin intake in the first month of pregnancy may be related to lower placental global DNA methylation and related to DNA methylation in brain-related pathways in both placenta and cord blood. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Occupational Health Pregnancy Safety
• Keywords:
  Author Keywords: DNA Methylation Cohort Studies Cord Blood DNA Damage Epigenetics Genomics Placenta Pregnancy Cohort Prenatal Vitamins Vitamins
• ISSN:
  1756-8935
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28
• Volume:
  15
• NIOSHTIC Number:
  nn:20070617
• Citation:
  Epigenetics Chromatin 2022 Aug; 15:28
• Contact Point Address:
  Kelly M. Bakulski, Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA
• Email:
  bakulski@umich.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epigenetics & Chromatin
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a0e46a751bdbd169ced05718ed0d0944c8347e478f6312f66eebd491b938bdf66003a5ca30449d8a977bf39d41fb7f38dad4329f0f4369db8ceae7be1ef2703
• Download URL:
  https://stacks.cdc.gov/view/cdc/208796/cdc_208796_DS1.pdf
• File Type:
  [PDF - 1.60 MB ]