A Meta-Analysis of Epigenome-Wide Association Studies on Pregnancy Vitamin B12 Concentrations and Offspring DNA Methylation

Details

• Personal Author:
  Bakulski KM ; Battram T ; Bustamante M ; Caramaschi D ; Dou J ; Felix JF ; Fernández-Barrés S ; Håberg SE ; Heil SG ; Hoang TT ; Jaddoe VWV ; Johnson L ; Küpers LK ; London SJ ; Mancano G ; Melén E ; Merid SK ; Monasso GS ; Nystad W ; Page CM ; Schmidt RJ ; Sharp GC ; Sunyer J ; Ueland PM ; Vrijheid M
• Description:
  Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n=2,420) or cord blood (n=1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value <0.05). Persistent associations with DNA methylation in the peripheral blood of up to 482 children aged 4-10y were observed for 40.7% of CpGs associated with maternal vitamin B12 and 57.1% of CpGs associated with newborn vitamin B12. Of the CpGs identified in the maternal meta-analyses, 4.6% were associated with either birth weight or gestational age in a previous work. For the newborn meta-analysis, this was the case for 14.3% of the identified CpGs. Also, of the CpGs identified in the newborn meta-analysis, 14.3% and 28.6%, respectively, were associated with childhood cognitive skills and nonverbal IQ. Of the 109 CpGs associated with maternal vitamin B12, 18.3% were associated with nearby gene expression. In this study, we showed that maternal and newborn vitamin B12 concentrations are associated with DNA methylation at multiple CpGs in offspring blood (PFDR<0.05). Whether this differential DNA methylation underlies associations of vitamin B12 concentrations with child health outcomes, such as birth weight, gestational age, and childhood cognition, should be further examined in future studies. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Genetics Occupational Health Pregnancy Safety
• Keywords:
  Author Keywords: Vitamin B12 Cohort Studies Cohort Study DNA Damage DNA Methylation Genomics Meta-analysis PACE Consortium Vitamins
• ISSN:
  1559-2294
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; North Carolina ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  1
• NIOSHTIC Number:
  nn:20070592
• Citation:
  Epigenetics 2024 Jan; 18(1):2202835
• Contact Point Address:
  Janine F. Feliz, Generation R Study Group (Na-2918), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
• Email:
  j.felix@erasmusmc.nl
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epigenetics
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d75ad2deb89cf95300c604b81f9039b4fad4ff476b1ebd032bf5bc17dbb91f04687208bda671ccc688eac948a89100959d35238f813d2789cc3a30db168de2ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/208772/cdc_208772_DS1.pdf
• File Type:
  [PDF - 3.15 MB ]