Statistical Methods in Cancer Research, Volume V: Bias Assessment in Case-Control and Cohort Studies for Hazard Identification

Details

• Corporate Authors:
  World Health Organization. International Agency for Research on Cancer
• Description:
  Observational epidemiology is used to identify the causes of cancer and other chronic diseases, to determine the effectiveness of interventions, and to understand reasons for differences in disease rates over time or across locations. Reviewers of observational epidemiology studies must judge whether a causal interpretation is supported, including whether chance, bias, and confounding can be reasonably ruled out. This Scientific Publication was supported by a scientific workshop on epidemiological bias assessment in hazard identification, convened by IARC and funded in part by the United States National Cancer Institute. It summarizes the wide range of practical methods that can be used by a reader or reviewer of a publication to assess the potential impact of confounding, information bias (including differential and non-differential exposure and outcome misclassification), or selection bias on the results of an epidemiological study. The methods presented include indirect approaches, for example negative control outcomes or exposures and proxies, and other approaches, such as sensitivity analyses. The methods are presented in a way that is accessible to epidemiologists and other research workers who do not have extensive statistical training, as well as to statisticians who do not have extensive epidemiological training. The concepts are illustrated with numerous practical examples, taken from cancer epidemiology, that recur throughout the chapters, as well as links to online code or spreadsheets. The book also outlines the process for integrating these bias assessments into the evidence synthesis. The process that is outlined uses the wide array of methods described in the book to consider all informative studies. Finally, it is hoped that this book will encourage authors to apply a wider range of direct and indirect bias assessments in their primary research publications. Broader adoption of these analyses will enhance the quality of the original papers and further improve the interpretation of the evidence in subsequent reviews. [Description provided by NIOSH]
• Subjects:
  Epidemiology Hazardous Substances Neoplasms Occupational Health Safety
• Keywords:
  Cancer Data Processing Hazard Identification Statistical Analysis Statistical Quality Control
• ISBN:
  9789283222293
• ISSN:
  0300-5085
• Publisher:
  International Agency for Research on Cancer (IARC)
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Atlanta Region [OSHA] ; Boston Region [OSHA] ; California ; Chicago Region [OSHA] ; Georgia ; Massachusetts ; Minnesota ; North Carolina ; Ohio ; Pennsylvania ; Philadelphia Region [OSHA] ; Rhode Island ; San Francisco Region [OSHA] ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering ; WTCHP - World Trade Center Health Program
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-243
• Volume:
  171
• NIOSHTIC Number:
  nn:20070516
• Citation:
  Statistical methods in cancer research, volume V: bias assessment in case-control and cohort studies for hazard identification. Berrington de González A, Richardson DB, Schubauer-Berigan MK, eds. Lyon, France: International Agency for Research on Cancer (IARC), IARC Scientific Publications No. 171, 2024 Oct; 171:1-345
• Editor(s):
  Berrington de González A; Richardson DB; Schubauer-Berigan MK
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  True
• Source Full Name:
  Statistical methods in cancer research, volume V: bias assessment in case-control and cohort studies for hazard identification
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0d02177d9b5b472589dd4799a3fcc9e9eaa16e5efdf519ae4bd012720ac7431f0a1300ba085f91e54f1ba00ee05fd890dd8b6690a4c87791a74682c70b3a6140
• Download URL:
  https://stacks.cdc.gov/view/cdc/208711/cdc_208711_DS1.pdf
• File Type:
  [PDF - 8.41 MB ]