In Utero Nano-Titanium Dioxide Exposure Results in Sexually Dimorphic Weight Gain and Cardiovascular Function in Offspring

Details

• Personal Author:
  Bowdridge E ; Gluth T ; Hunter R ; Meadows E ; Nett R ; Nist V
• Description:
  Engineered nanomaterials (ENM) are capable of crossing the placental barrier and accumulating in fetal tissue. Specifically, the ENM nano-titanium dioxide (nano-TiO2), has been shown to accumulate in placental and fetal tissue, resulting in decreased birthweight in pups. Additionally, nano-TiO2 is an established cardiac toxicant and regulator of glucose homeostasis, and exposure in utero may lead to serious maladaptive responses in cardiac development and overall metabolism. The current study examines weight gain and cardiac function in male and female Sprague-Dawley rats exposed to 12 mg/m3 nano-TiO2 or filtered air for 6 non-consecutive days in utero between gestational days 12-19. These animals were randomly assigned to receive a grain-based or high-fat diet (60%) between postnatal weeks 12-24 to examine the propensity for weight gain and cardiac response as adults. Our results show a sexually dimorphic response to weight gain with male rats gaining more weight after high-fat diet following in utero nano-TiO2 exposure, and female rats gaining less weight on the high-fat diet respective of exposure. Male rats exposed to nano-TiO2 in utero had reduced ejection fraction prior to diet when compared to air controls. Female rats subjected to in utero nano-TiO2 exposure showed a significant decrease in cardiac output following 12 weeks of high-fat diet. Development of cardiovascular impairments and ultimately cardiac dysfunction and disease following in utero exposures highlights the need for occupational and environmental monitoring of nanoparticulate exposure. [Description provided by NIOSH]
• Subjects:
  Body Weight Diet Energy Metabolism Occupational Health Pregnancy Safety Titanium
• Keywords:
  Author Keywords: Cardiac Body Weight Cardiovascular Function In Utero Exposure Metabolism Nanomaterial Nanomaterials Sexually Dimorphic Titanium Dioxide
• ISSN:
  1530-7905
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  354-364
• Volume:
  25
• Issue:
  3
• NIOSHTIC Number:
  nn:20070471
• Citation:
  Cardiovasc Toxicol 2025 Mar; 25(3):354-364
• Contact Point Address:
  Elizabeth Bowdridge, Department of Physiology, Pharmacology, and Toxicology, West Virginia University, Morgantown, WV 26505
• Email:
  ebowdrid@hsc.wvu.edu
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2025
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20220901
• Source Full Name:
  Cardiovascular Toxicology
• End Date:
  20230831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f88ed5f3a3bfe9209f6a0e05a9db9947457b1bd6caba5886ae9629d48ecc99fc3a600b897bf8b954ddb0b1043c4122c85e0346a2327c49af2bcd86fa40a332a9
• Download URL:
  https://stacks.cdc.gov/view/cdc/208672/cdc_208672_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]