Preconception and First Trimester Exposure to Pesticides and Associations with Stillbirth

Details

• Personal Author:
  Arellano AF ; Beamer PI ; Bedrick EJ ; Cockburn MG ; Ellsworth PC ; Fournier AJ ; Furlong MA ; Parra KL ; Paul KC ; Ritz B
• Description:
  Associations of pesticide exposures during preconception with stillbirth have not been well explored. We linked Arizona pesticide use records with birth certificates from 2006 to 2020 and estimated associations of living within 500 m of any pyrethroid, organophosphate (OP), or carbamate pesticide applications during a 90-day preconception window or the first trimester, with stillbirth. We considered a binary measure of exposure (any exposure), as well as log-pounds and log-acres applied within 500 m, in a negative control exposure framework with log-binomial regression. We included 1 237 750 births, 2290 stillbirths, and 27 pesticides. During preconception, any exposure to pesticides was associated with stillbirth, including cyfluthrin (risk ratio [RR] = 1.97; 95% CI, 1.17-3.32); zeta-cypermethrin (RR = 1.81; 95% CI, 1.20-2.74); OPs as a class (RR = 1.60; 95% CI, 1.16-2.19); malathion (RR = 2.02; 95% CI, 1.26-3.24); carbaryl (RR = 6.39; 95% CI, 2.07-19.74); and propamocarb hydrochloride (RR = 7.72; 95% CI, 1.10-54.20). During the first trimester, fenpropathrin (RR = 4.36; 95% CI, 1.09-17.50); permethrin (RR = 1.57; 95% CI, 1.02-2.42); OPs as a class (RR = 1.50; 95% CI, 1.11-2.01); acephate (RR = 2.31; 95% CI, 1.22-4.40); and formetanate hydrochloride (RR = 7.22; 95% CI, 1.03-50.58) were associated with stillbirth. Interpretations were consistent when using continuous measures of pounds or acres of exposure. Pesticide exposures during preconception and first trimester may be associated with stillbirth. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Epidemiology Insecticides Occupational Health Pregnancy Safety Urogenital System
• Keywords:
  Author Keywords: Pesticides Carbamate Pesticides Environmental Exposure Environmental Exposures Fetal Death Miscarriage Organophosphate Pesticides Pesticides Prenatal Exposure Pyrethroid Pesticides Reproductive Health Stillbirth

  More +
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; California ; San Francisco Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  44-55
• Volume:
  194
• Issue:
  1
• NIOSHTIC Number:
  nn:20070463
• Citation:
  Am J Epidemiol 2025 Jan; 194(1):44-55
• Contact Point Address:
  Melissa Furlong, Department of Community, Environment, and Policy, Environmental Health Sciences, University of Arizona, 1295 N Martin Avenue, Tucson AZ
• Email:
  mfurlong@arizona.edu
• Federal Fiscal Year:
  2025
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8cce2d3013be662a2c55ebe01b1d4f7540ed36866fbc1f4d6548db9d7cf099b900477987af802e4b963ef2578c04f3d67e343bb96626f8fce3161967c121b38c
• Download URL:
  https://stacks.cdc.gov/view/cdc/208665/cdc_208665_DS1.pdf
• File Type:
  [PDF - 962.20 KB ]