Applied Pressure Alters Circulating Hormone Levels and Biomarkers of Peripheral Vascular, Sensorineural Dysfunction (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Workers that regularly use vibrating hand tools as part of their job are at risk of developing hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms that result in blanching of the fingers and hands, loss of sensation, pain, and reductions in manual dexterity, all of which can affect a worker's ability to perform their job and their quality of life. Vibration exposure significantly contributes to the development of these symptoms by increasing the stress and strain within exposed tissues, which in turn can affect functioning of blood vessels, nerves and sensory receptors in those tissues. The International Standards Organization (ISO) standard 5349 provides guidance to help employers and workers predict if workers are at risk of developing HAVS. To date, most of the data presented in the standard have focused specifically on the effects of vibration. However, the standard states that other risk factors are likely to contribute, such as the force applied to exposed tissues when a worker is using a hand-tool, the posture of the worker, the environment the worker is working in, and various other personal health-related factors. The goal of this study was to characterize the effects of applied force, and applied force plus vibration on vascular and sensorineural function. The rat-tail model for studying force and vibration, established at NIOSH, was used in this study. The effects of 10 days of exposure to 2 or 4N of applied force on circulating hormone concentrations, transcript expression, immunostaining for various markers of oxidative stress, growth and remodeling, and tissue morphology to determine what the effects of applied force are on exposed skin, arteries, nerves, and other tissues involved in sensorineural function including the dorsal root ganglia (DRG) and spinal cord. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Safety Vibration
• Keywords:
  Hand-arm Vibration Syndrome Hand Tools HAVS Hormone Activity Peripheral Nervous System Sensory Disorders Vibration Exposure
• DOI:
  https://doi.org/10.26616/NIOSHRD-1099-2024-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070357
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1099-2024-0, 2024 Dec; :dataset
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  False
• Source Full Name:
  Applied pressure alters circulating hormone levels and biomarkers of peripheral vascular, sensorineural dysfunction
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:459fe476069b35cf2ebb185f868251607339d0df3d814fe3da420f67db2d9eab965c4a04fb6f8fccc68a8e56adb2c2be779b4a1813cb14b4e0236b06b3e97363
• Download URL:
  https://stacks.cdc.gov/view/cdc/208589/cdc_208589_DS1.pdf
• File Type:
  [PDF - 191.69 KB ]