Force-Induced Tissue Compression Alters Circulating Hormone Levels and Biomarkers of Peripheral Vascular and Sensorineural Dysfunction in an Animal Model of Hand-Arm Vibration Syndrome

Details

• Personal Author:
  Chapman P ; Dong, Ren G. ; Hammer M ; Krajnak, Kristine M. ; Richardson D ; Warren C ; Waugh, Stacey ; Welcome, Daniel E. ; Xu X
• Description:
  Workers regularly using vibrating hand tools may develop a disorder referred to as hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms in the hands and fingers that result in blanching of the skin, loss of sensory function, pain, and reductions in manual dexterity. Exposure to vibration induces some of these symptoms. However, the soft tissues of the hands and fingers of workers are compressed as a result of the force generated when a worker grips a tool. The compression of these soft tissues might also contribute to the development of HAVS. The goal of this study was to use an established rat tail model to determine the mechanisms by which compression of the tail tissues affects (1) the ventral tail artery (VTA) and ventral tail nerves (VTN), (2) nerves and sensory receptors in the skin, (3) dorsal root ganglia (DRG), and (4) spinal cord. Tissue compression resulted in the following changes (1) circulating pituitary and steroid hormone concentrations, (2) expression of factors that modulate vascular function in the skin and tail artery, and (3) factors associated with nerve damage, DRG, and spinal cord. Some of these observed effects differed from those previously noted with vibration exposure. Based upon these findings, the effects of applied force and vibration are different. Studies examining the combination of these factors might provide data that may potentially be used to improve risk assessment and support revision of standards. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Safety Vibration
• Keywords:
  Arteries Author Keywords: Tissue Compression Hand-arm Vibration Syndrome Hand Tools HAVS Hormone Activity Nerves Peripheral Nervous System Peripheral Sensory System Sensory Disorders Vibration Exposure

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  175-195
• Volume:
  88
• Issue:
  5
• NIOSHTIC Number:
  nn:20070327
• Citation:
  J Toxicol Environ Health A 2025 Mar; 88(5):175-195
• Contact Point Address:
  Kristine Krajnak, Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6f3907fe9341ec4ff71137872ba8b030628c655083e78befe34db2c136c899dd67568af1778e6945758b181c1dc8e0d516600388c007ee46ed4cdfec3591b302
• Download URL:
  https://stacks.cdc.gov/view/cdc/208561/cdc_208561_DS1.pdf
• File Type:
  [PDF - 3.93 MB ]