Carcinogenicity of Talc and Acrylonitrile

Details

• Personal Author:
  Ahmadi A ; Benbrahim-Tallaa L ; Blanco J ; Cardenas A ; Carreon-Valencia, Tania ; Chittiboyina S ; Consonni D ; Davies L ; de Conti A ; De Matteis S ; Demers PA ; Facchin C ; Felley-Bosco E ; Fritz JM ; Ghio AJ ; Göen T ; Grosse Y ; Gualtieri AF ; Josephy PD ; Koutros S ; Kulasingam S ; Kunzmann A ; Linhart I ; Louro H ; MacLehose R ; Madia F ; Mattock H ; Motlhale M ; O'Brien KM ; Panzacchi S ; Pasqual E ; Peña L ; Rössner P ; Schildkraut JM ; Schubauer-Berigan, Mary K. ; Shah S ; Sim, Malcolm R. ; Stayner, Leslie T. ; Stefaniak, Aleksandr B. ; Stewart P ; Suonio E ; Tsuda H ; Wedekind R ; Wentzensen N ; Wild P ; Xu Y
• Description:
  In June, 2024, a Working Group of 29 scientists from 13 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of talc and acrylonitrile. Acrylonitrile was classified as "carcinogenic to humans" (Group 1) based on "sufficient" evidence for cancer in humans. There was also "sufficient" evidence for cancer in experimental animals and "strong" mechanistic evidence in experimental systems. Talc was classified as "probably carcinogenic to humans" (Group 2A) based on a combination of "limited" evidence for cancer in humans, "sufficient" evidence for cancer in experimental animals, and "strong" mechanistic evidence in human primary cells and experimental systems. This evaluation supersedes the previous classifications of "talc not containing asbestos or asbestiform fibres" and "perineal use of talc-based body powder" in Volume 93 of the IARC Monographs. These assessments will be published in Volume 136 of the IARC Monographs. "Talc containing asbestos" was not re-evaluated and retains its classification within "asbestos" (Group 1) from Volume 100C. [Description provided by NIOSH]
• Subjects:
  Carcinogens Neoplasms Occupational Health Safety Talc
• Keywords:
  Acrylonitrile Cancer Carcinogenicity Carcinogen Policy
• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  8
• NIOSHTIC Number:
  nn:20070348
• Citation:
  Lancet Oncol 2024 Aug; 25(8):962-963
• CAS Registry Number:
  Acrylonitrile (CAS RN 107-13-1) ; Talc (Mg3H2(SiO3)4) (CAS RN 14807-96-6)
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  False
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b84005ecfc62377549691b18c8ecc1a231d1a12c1954154fda9c91fbf1c4dd4a1b8547ad61c59abb47c205e41d483c3ef1676148a34bf134b015b56477f32d7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/208580/cdc_208580_DS1.pdf
• File Type:
  [PDF - 102.88 KB ]