DNA Methylation as a Molecular Mechanism of Carcinogenesis in World Trade Center Dust Exposure: Insights from a Structured Literature Review

Details

• Personal Author:
  Arslan AA ; Chen Y ; Durmus N ; Reibman J ; Shao Y ; Snuderl M ; Taioli E ; Tuminello S
• Description:
  The collapse of the World Trade Center (WTC) buildings in New York City generated a large plume of dust and smoke. WTC dust contained human carcinogens including metals, asbestos, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs, including polychlorinated biphenyls (PCBs) and dioxins), and benzene. Excess levels of many of these carcinogens have been detected in biological samples of WTC-exposed persons, for whom cancer risk is elevated. As confirmed in this structured literature review (n studies = 80), all carcinogens present in the settled WTC dust (metals, asbestos, benzene, PAHs, POPs) have previously been shown to be associated with DNA methylation dysregulation of key cancer-related genes and pathways. DNA methylation is, therefore, a likely molecular mechanism through which WTC exposures may influence the process of carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dust Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: DNA Methylation DNA Damage Dust Exposure Epigenetics Gene Expression Molecular Biology World Trade Center WTC
• ISSN:
  2218-273X
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; New York City Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  10
• NIOSHTIC Number:
  nn:20070267
• Citation:
  Biomolecules 2024 Oct; 14(10):1302
• Contact Point Address:
  Emanuela Taioli, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029
• Email:
  emanuela.taioli@mountsinai.org
• Federal Fiscal Year:
  2025
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  Biomolecules
• End Date:
  20230630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b0cc8cdc8d4791f35f2b6fe5b752dee18c16cc577d888e9888ce9b33d65ff0d3f5efae68d9b2c8e55727d2bc62998089cfacfa47e5d535bffe34090fcb7a9af8
• Download URL:
  https://stacks.cdc.gov/view/cdc/208514/cdc_208514_DS1.pdf
• File Type:
  [PDF - 773.54 KB ]