World Trade Center Tissue Biobank

Details

• Personal Author:
  Taioli E
• Description:
  Biospecimen resources and their clinical annotations are among some of the most powerful resources fueling translational research. The tissue bank represents the necessary infrastructure for addressing questions such as the link between specific carcinogens exposures and cancer developed in certain sites such as prostate and thyroid, molecular signatures of exposure, which could be linked to cancer, and specific markers of tumor aggressiveness among WTC responders. This project has several important innovative aspects, including the comparison of human and animal response to exposure to WTC carcinogens. This project gives the opportunity for the first time to compare systemic and local changes observed in rodents exposed in a controlled fashion to WTC dust to what is observed in human peripheral blood, normal and cancer tissues of WTC responders Comparative research between animal and human studies is highly translational and may play a central role in understanding if there is an association between WTC exposure and tumor biology and aggressiveness. Thus, the proposed inclusion of both human and animal tissue banking will provide a new platform to facilitate examination of the underlying mechanisms of cancer development associated with WTC exposure. The WTCHP runs separate data sets containing comprehensive clinical information and details on environmental exposures that occurred at the WTC site. These data sets can be conveniently linked with the biobank, thus providing future investigators endless possibilities for studies on cancer etiology, biology and outcome in the WTC population. A bank of peripheral blood collected at the time of enrollment in the WTCHP is also available and can be linked to each cancer case. This will facilitate studies of the systemic inflammatory and immuno- response in the immediate aftermath of the disaster, along with analyses of WTC toxicants and carcinogens in the blood that could be linked to the subsequent cancer development. Another key element is that these rodents are exposed to different doses of WTC dust and for different time spans, thus available tissues will reflect and mimic both the intensity and the duration of exposure that occurred in WTC responders. The tissue bank offers both human and animal biological specimens for comparison; the results are analyzed in conjunction with the exposure, epidemiologic and clinical information available from the WTCHP. The biobank will facilitate translational studies that for the first time will give a comprehensive view of the effect of WTC exposure on cancer etiology, occurrence and aggressiveness. Examples of various multicentric, collaborative biomarkers studies which have used tissues are: DNA methylation as a consequence of environmental exposure to carcinogens and prostate cancer, comparison of local tissue markers of inflammation in prostate tumors from WTC responders and in cancer patients not related to the WTC event, staining of thyroid cancer tissues to assess false positive diagnoses, HPV study on head and neck cancer tissues. All these studies are using the WTC tissue bank and would benefit from confirming their findings in corresponding tissues from organs of animals experimentally exposed to WTC dust. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Dust Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Biological Materials Cancer Dust Exposure Tissue Culture World Trade Center WTC
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-7
• NIOSHTIC Number:
  nn:20069962
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011704, 2023 Oct; :1-7
• Contact Point Address:
  Emanuela Taioli, MD, PhD, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Pl, New York, NY, 10029-6574
• Email:
  Emanuela.taioli@mountsinai.org
• Federal Fiscal Year:
  2024
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20180701
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d26d4a3193c6eb98bf862f6b9ce357366a11f3af597beae0583dfdcc70be0f591aa22177625d5149ba136d73cdc1809b6d64ba25f6b368b02b28d8b486a7e6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/219266/cdc_219266_DS1.pdf
• File Type:
  [PDF - 210.17 KB ]