Endogenous Chemerin Limits the Severity of Ozone-Induced Airway Hyperresponsiveness Irrespective of Body Mass

Details

• Personal Author:
  Boots T ; Johnston R ; Pilkington A ; Takahashi M ; Takahashi Y
• Description:
  Rationale: Tumor necrosis factor-a, a pleiotropic adipocytokine, limits the severity of airway hyperresponsiveness (AHR), a cardinal feature of asthma, in obese mice exposed to ozone (O3), a criteria pollutant and non-atopic asthma stimulus. However, in this phenomenon, the contribution of chemerin, an adipocytokine and non-chemokine chemoattractant for natural killer cells, macrophages and plasmacytoid dendritic cells, is unknown. Consequently, our goal was to asseverate the relevance of chemerin in the development of O3-induced AHR in obesity. Methods: Wild-type C57BL/6J mice and mice genetically deficient in chemerin (chemerin-deficient mice) were fed standard chow or a diet consisting of 60 kcal % fat (high-fat diet; HFD) from weaning until 30 weeks of age. At 30 weeks of age, mice were exposed to either filtered room air (air) or O3 (2 ppm) for three hours. Twenty-four hours following cessation of exposure, indices of airway responsiveness to methacholine [airway resistance and coefficients of lung tissue damping and elastance] were measured using the forced oscillation technique. Results: Consumption of a HFD by wild-type and chemerin-deficient mice led to obesity. Following air exposure, airway responsiveness to methacholine was greater in chemerin-deficient as compared to wild-type mice irrespective of the diet consumed. All mice exposed to O3 exhibited AHR. Nevertheless, regardless of the diet consumed, airway responsiveness was greater in chemerin-deficient as compared to wild-type mice following O3 exposure. Conclusions: Chemerin limits the severity of airway responsiveness in the presence and absence of inciting stimuli and may be a therapeutic target to limit exaggerated airway narrowing observed in obese and non-obese asthmatics. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Diet Immune System Occupational Health Ozone Respiratory System Safety
• Keywords:
  Immune Reaction Inhalation Studies Obesity
• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  153
• Issue:
  2
• NIOSHTIC Number:
  nn:20070243
• Citation:
  J Allergy Clin Immunol 2024 Feb; 153(2)(Suppl):AB256
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1f52101187504f6fbbd0cf13032a8987c2b40dbf92daa2d3b1140a4077ed152db6533239b957cbd2da3ce0a88b35443b9e660235c0f6068e503caeb03bcbdf37
• Download URL:
  https://stacks.cdc.gov/view/cdc/208492/cdc_208492_DS1.pdf
• File Type:
  [PDF - 125.81 KB ]