Wristband Personal Passive Samplers and Suspect Screening Methods Highlight Gender Disparities in Chemical Exposures

Details

• Personal Author:
  Allen JG ; Ferguson PL ; Getzinger GJ ; Herkert NJ ; Hoffman K ; Levasseur JL ; Stapleton HM ; Young AS
• Description:
  Wristband personal samplers enable human exposure assessments for a diverse range of chemical contaminants and exposure settings with a previously unattainable scale and cost-effectiveness. Paired with nontargeted analyses, wristbands can provide important exposure monitoring data to expand our understanding of the environmental exposome. Here, a custom scripted suspect screening workflow was developed in the R programming language for feature selection and chemical annotations using gas chromatography-high-resolution mass spectrometry data acquired from the analysis of wristband samples collected from five different cohorts. The workflow includes blank subtraction, internal standard normalization, prediction of chemical uses in products, and feature annotation using multiple library search metrics and metadata from PubChem, among other functionalities. The workflow was developed and validated against 104 analytes identified by targeted analytical results in previously published reports of wristbands. A true positive rate of 62 and 48% in a quality control matrix and wristband samples, respectively, was observed for our optimum set of parameters. Feature analysis identified 458 features that were significantly higher on female-worn wristbands and only 21 features that were significantly higher on male-worn wristbands across all cohorts. Tentative identifications suggest that personal care products are a primary driver of the differences observed. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Occupational Health Safety Sex Characteristics
• Keywords:
  Author Keywords: Wristbands Chemical Exposure Environmental Exposure Exposome Exposure Assessment Gender Factors Monitoring Systems Personal Samplers Sampling Methods Suspect Screening Wearable Technologies

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• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  35
• NIOSHTIC Number:
  nn:20070140
• Citation:
  Environ Sci Technol 2024 Sep; 58(35):15497-15510
• Contact Point Address:
  Heather M. Stapleton, Nicholas School of the Environment, Duke University, Durham, North Carolina 27710, United States
• Email:
  heather.stapleton@duke.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f439e218b9de63aca15f6a13477aa783caa5748113a5d67e60ee570a4d7a5e1c9f39bbf1a4e2e9237b1964b221f4e736e3c6f9d03943c8a2fc92dcbd3d055e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/208420/cdc_208420_DS1.pdf
• File Type:
  [PDF - 4.82 MB ]