Site-Specific Cancer Mortality After Low Level Exposure to Ionizing Radiation: Findings from an Update of the International Nuclear Workers Study (INWORKS)

Details

• Personal Author:
  Bertke S ; Daniels, Robert D. ; Gillies M ; Haylock R ; Kelly-Reif K ; Kesminiene A ; Laurier D ; Leuraud K ; Moissonnier M ; Richardson DB ; Schubauer-Berigan, Mary K. ; Thierry-Chef I
• Description:
  A major update to the International Nuclear Workers Study was undertaken that allows us to report updated estimates of associations between radiation and site-specific solid cancer mortality. A cohort of 309,932 nuclear workers employed in France, the United Kingdom, and United States were monitored for external radiation exposure and associations with cancer mortality were quantified as the excess relative rate (ERR) per gray (Gy) using a maximum likelihood and a Markov chain Monte Carlo method (to stabilize estimates via a hierarchical regression). The analysis included 28,089 deaths due to solid cancer, the most common being lung, prostate, and colon cancer. Using maximum likelihood, positive estimates of ERR per Gy were obtained for stomach, colon, rectum, pancreas, peritoneum, larynx, lung, pleura/mesothelioma, bone and connective tissue, skin, prostate, testis, bladder, kidney, thyroid, and residual cancers; negative estimates of ERR per Gy were found cancers of oral cavity and pharynx, esophagus, and ovary. A hierarchical model stabilized site-specific estimates of association, including for lung (ERR per Gy=0.65; 95% credible interval [CrI]: 0.24, 1.07), prostate (ERR per Gy=0.44; 95% CrI: -0.06, 0.91), and colon cancer (ERR per Gy=0.53; 95% CrI: -0.07, 1.11). The results contribute evidence regarding associations between low dose radiation and cancer. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Mortality Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Cohort Studies Cancer Cancer Rates Cohort Studies Ionizing Radiation Mortality Data Mortality Study Nuclear Workers Occupational Exposure Occupational Exposures Radiation Exposure

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering ; WTCHP - World Trade Center Health Program
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070009
• Citation:
  Am J Epidemiol 2024 Aug; :[Epub ahead of print]
• Contact Point Address:
  David Richardson, Department of Environmental and Occupational Health, Program in Public Health, University of California, Irvine, CA, USA 92697
• Email:
  david.richardson@uci.edu
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f3190b36a98ec23271a38f920f2c0f8b8e1ed6812419346a2bc8288a97a9b24e72218e432ce7e1fd7739973b57e0501e52d39025cf1b091b518381d78cb5af2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/208318/cdc_208318_DS1.pdf
• File Type:
  [PDF - 1.77 MB ]