3D-Printed Flexible Microfluidic Health Monitor for In Situ Sweat Analysis and Biomarker Detection

Details

• Personal Author:
  Boddeti N ; Chen C ; Ding S ; Du D ; Fu Y ; Lin Y ; Liu Y ; Lyu Z ; Pradhan A ; Qiu K ; Sparks SS
• Description:
  Wearable sweat biosensors have shown great progress in noninvasive, in situ, and continuous health monitoring to demonstrate individuals' physiological states. Advances in novel nanomaterials and fabrication methods promise to usher in a new era of wearable biosensors. Here, we introduce a three-dimensional (3D)-printed flexible wearable health monitor fabricated through a unique one-step continuous manufacturing process with self-supporting microfluidic channels and novel single-atom catalyst-based bioassays for measuring the sweat rate and concentration of three biomarkers. Direct ink writing is adapted to print the microfluidic device with self-supporting structures to harvest human sweat, which eliminates the need for removing sacrificial supporting materials and addresses the contamination and sweat evaporation issues associated with traditional sampling methods. Additionally, the pick-and-place strategy is employed during the printing process to accurately integrate the bioassays, improving manufacturing efficiency. A single-atom catalyst is developed and utilized in colorimetric bioassays to improve sensitivity and accuracy. A feasibility study on human skin successfully demonstrates the functionality and reliability of our health monitor, generating reliable and quantitative in situ results of sweat rate, glucose, lactate, and uric acid concentrations during physical exercise. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Printing, Three-Dimensional Safety
• Keywords:
  3D Printing Author Keywords: Wearable Health Monitor Biomarker Detection Biosensors Monitors Nanomaterials Self-supporting Microfluidics Single-atom Catalyst Sweat Analysis Three Dimensional Printing Wearable Technologies

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• ISSN:
  2379-3694
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  6
• NIOSHTIC Number:
  nn:20069873
• Citation:
  ACS Sens 2024 Jun; 9(6):3212-3223
• Contact Point Address:
  Dan Du, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States
• Email:
  annie.du@wsu.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Washington State University
• Peer Reviewed:
  True
• Start Date:
  20230901
• Source Full Name:
  ACS Sensors
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf64dab7c78bf5f51756e7bbb02b2d98a2d3a727cbc53080456ba5377e25a1c638b109e33adb6b7ac02962c4f07996a4de5796aec8fce4cf1e2d9ea11eb3b803
• Download URL:
  https://stacks.cdc.gov/view/cdc/208213/cdc_208213_DS1.pdf
• File Type:
  [PDF - 8.08 MB ]