Serum Alarmins and the Risk of Incident Interstitial Lung Disease in Rheumatoid Arthritis

Details

• Personal Author:
  Baker JF ; Cannon GW ; Duryee MJ ; England BR ; Hunter CD ; Johnson TM ; Joseph AM ; Kerr GS ; Kunkel G ; Mikuls TR ; Poole JA ; Sauer BC ; Sayles H ; Thiele GM ; Wallace BI ; Wysham KD
• Description:
  Objectives: To quantify associations of serum alarmins with risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Methods: Using serum collected at enrolment, three alarmins (IL-33, thymic stromal lymphopoietin [TSLP] and IL-25) were measured in a multicentre prospective RA cohort. ILD was classified using systematic medical record review. Cross-sectional associations of log-transformed (IL-33, TSLP) or quartile (IL-25) values with RA-ILD at enrolment (prevalent RA-ILD) were examined using logistic regression, while associations with incident RA-ILD developing after enrolment were examined using Cox proportional hazards. Covariates in multivariate models included age, sex, race, smoking status, RA disease activity score and anti-cyclic citrullinated antibody positivity. Results: Of 2835 study participants, 115 participants (4.1%) had prevalent RA-ILD at baseline and an additional 146 (5.1%) developed incident ILD. There were no associations between serum alarmin concentrations and prevalent ILD in unadjusted or adjusted logistic regression models. In contrast, there was a significant inverse association between IL-33 concentration and the risk of developing incident RA-ILD in unadjusted (hazard ratio [HR] 0.73 per log-fold increase; 95% CI: 0.57, 0.95; P = 0.018) and adjusted (HR 0.77; 95% CI: 0.59, 1.00; P = 0.047) models. No significant associations of TSLP or IL-25 with incident ILD were observed. Conclusion: In this study, we observed a significant inverse association between serum IL-33 concentration and the risk of developing incident RA-ILD, but no associations with prevalent ILD. Additional investigation is required to better understand the mechanisms driving this relationship and how serum alarmin IL-33 assessment might contribute to clinical risk stratification in patients with RA. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Fibrosis Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Alarmin Cohort Studies Interleukin-25 Interleukin-33 Interstitial Lung Disease Lung Disease Medical Records Rheumatoid Arthritis Rheumatoid Disorders Thymic Stromal Lymphopoietin
• ISSN:
  1462-0324
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Michigan ; Missouri ; Nebraska ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 8 ; Pennsylvania ; Utah ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  63
• Issue:
  7
• NIOSHTIC Number:
  nn:20069850
• Citation:
  Rheumatology 2024 Jul; 63(7):1998-2005
• Contact Point Address:
  Ted R. Mikuls, Division of Rheumatology and Immunology, 986270 Nebraska Medical Center, Omaha, NE 68198-6270
• Email:
  tmikuls@unmc.edu
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Rheumatology
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0504dbf180c5d5b5a296cf004d53ef63a0b073d7127a4f3ee77187c6dc9b75c7b327dd4678b9abb54852e3ca9f5794e747e42eca6763bdc5d9c38f3a4991656c
• Download URL:
  https://stacks.cdc.gov/view/cdc/208195/cdc_208195_DS1.pdf
• File Type:
  [PDF - 498.37 KB ]