Combining Nontargeted Analysis with Computer-Based Hazard Comparison Approaches to Support Prioritization of Unregulated Organic Contaminants in Biosolids

Details

• Personal Author:
  Lyu Q ; Nachman KE ; Newmeyer MN ; Prasse C ; Sobus JR ; Williams AJ
• Description:
  Biosolids are a byproduct of wastewater treatment that can be beneficially applied to agricultural land as a fertilizer. While U.S. regulations limit metals and pathogens in biosolids intended for land applications, no organic contaminants are currently regulated. Novel techniques can aid in detection, evaluation, and prioritization of biosolid-associated organic contaminants (BOCs). For example, nontargeted analysis (NTA) can detect a broad range of chemicals, producing data sets representing thousands of measured analytes that can be combined with computational toxicological tools to support human and ecological hazard assessment and prioritization. We combined NTA with a computer-based tool from the U.S. EPA, the Cheminformatics Hazard Comparison Module (HCM), to identify and prioritize BOCs present in U.S. and Canadian biosolids (n = 16). Four-hundred fifty-one features were detected in at least 80% of samples, with identities of 92 compounds confirmed or assigned probable structures. These compounds were primarily categorized as endogenous compounds, pharmaceuticals, industrial chemicals, and fragrances. Examples of top prioritized compounds were p-cresol and chlorophene, based on human health end points, and fludioxonil and triclocarban, based on ecological health end points. Combining NTA results with hazard comparison data allowed us to prioritize compounds to be included in future studies of the environmental fate and transport of BOCs. [Description provided by NIOSH]
• Subjects:
  Environmental Pollution Fertilizers Occupational Health Safety
• Keywords:
  Author Keywords: Wastewater Biological Materials Chemical Space Ecological Systems Environmental Contamination Environmental Monitoring Environmental Technology High-resolution Mass Spectrometry Sludge Waste Treatment
• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  27
• NIOSHTIC Number:
  nn:20069842
• Citation:
  Environ Sci Technol 2024 Jul; 58(27):12135-12146
• Contact Point Address:
  Carsten Prasse, Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland 21205, United States
• Email:
  cprasse1@jhu.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:feac35695fef55445b36376ac211308a6720d7c1618c500a111b5616092690c656abda9def3bed9ea1e7bca1c3c366c485faf04033608aba048234650a9d54f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/208188/cdc_208188_DS1.pdf
• File Type:
  [PDF - 3.28 MB ]