Lack of Association of Impaired Upper Airway Sensation with the Presence or Absence of Obstructive Sleep Apnoea or Chronic Rhinosinusitis in World Trade Center Responders

Details

• Personal Author:
  Ayappa I ; Black K ; de la Hoz RE ; De Resende A ; Legard A ; Lu S-E ; Mullins AE ; Rapoport DM ; Ravi SS ; Romero Castillo H ; Sunderram J ; Udasin IG
• Description:
  Objective: Examine sensory function of the upper airway in four groups of subjects recruited from the World Trade Centre General Responder Cohort (WTCGRC), with/without obstructive sleep apnoea (OSA), and with/without chronic rhinosinusitis (CRS). Methods: Upper airway sensory function was determined using 2-point discrimination (2-PD) and vibration threshold (VT) in 163 WTCGRC subjects with both OSA and CRS (cases), OSA or CRS alone and without OSA or CRS (controls). Presence of OSA was determined from clinical sleep studies or home sleep testing. Presence of CRS was determined by nasal symptom questionnaire. The relationship between the presence of OSA and CRS and upper airway sensory impairment was assessed using linear regression analysis with each of 2PD and VT sensory threshold values as the dependent variable; OSA, CRS and their interaction were the independent variables. Age, gender and body mass index were covariates in the statistical model. The primary analysis was comparison of OSA+CRS versus controls (no OSA and no CRS) evaluated by linear contrasts. Results: There were no differences in 2-PD or VT in those with OSA+CRS, OSA and CRS alone or controls. However, both 2-PD and VT were significantly higher in the WTCGRC controls compared with values seen in historical controls using the same methodology (median 2-PD 13.0; CI (11.0 to 13.5) vs 10.5; CI (8 to 11); VT: mean+/-SEM (9.3+/-0.6 vs 2.2+/-0.1)). Conclusion: While no differences were found in upper airway sensation between cases of OSA and CRS versus controls in the WTGRC population, there was evidence of impaired upper airway sensation in the WTGRC overall. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Dust Emergency Responders Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cohort Studies Dust Exposure First Responders Sensory Disorders Sleep Apnea World Trade Center WTC
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  302-307
• Volume:
  81
• Issue:
  6
• NIOSHTIC Number:
  nn:20069805
• Citation:
  Occup Environ Med 2024 Jun; 81(6):302-307
• Contact Point Address:
  Dr Jag Sunderram, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903
• Email:
  sunderja@rwjms.rutgers.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20180701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c2d3d0f18dc3b24d8b970c021421083f5292c401a6e2ced6406cdf303ce959cf7e585bd58262fb050d54f44e3556f760a52555160e75262684019e79aaf354e
• Download URL:
  https://stacks.cdc.gov/view/cdc/208160/cdc_208160_DS1.pdf
• File Type:
  [PDF - 356.56 KB ]