Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material

Details

• Personal Author:
  Chiu EY ; Hunsaker HC ; Madl AK ; Nguyen TB ; Pinkerton KE ; Poulin BA ; Tran LN ; Wu K-C
• Description:
  Aerosol formation and production yields from 11 carbonyls (carbonyl concentration per aerosol mass unit) were investigated (1) from a fourth-generation (4th gen) e-cigarette device at different coil resistances and coil age (0-5000 puffs) using unflavored e-liquid with 2% benzoic acid nicotine salt, (2) between a sub-ohm third-generation (3rd gen) tank mod at 0.12 O and a 4th gen pod at 1.2 O using e-liquid with nicotine salt, together with nicotine yield, and (3) from 3rd gen coils of different metals (stainless steel, kanthal, nichrome) using e-liquid with freebase nicotine. Coil resistance had an inverse relationship with coil temperature, and coil temperature was directly proportional to aerosol mass formation. Trends in carbonyl yields depended on carbonyl formation mechanisms. Carbonyls produced primarily from thermal degradation chemistry (e.g., formaldehyde, acetaldehyde, acrolein, propionaldehyde) increased per aerosol mass with higher coil resistances, despite lower coil temperature. Carbonyls produced primarily from chemistry initiated by reactive oxygen species (ROS) (e.g., hydroxyacetone, dihydroxyacetone, methylglyoxal, glycolaldehyde, lactaldehyde) showed the opposite trend. Coil age did not alter coil temperature nor aerosol mass formation but had a significant effect on carbonyl formation. Thermal carbonyls were formed optimally at 500 puffs in our study and then declined to a baseline, whereas ROS-derived carbonyls showed a slow rise to a maximum trend with coil aging. The 3rd gen versus 4th gen device comparison mirrored the trends in coil resistance. Nicotine yields per aerosol mass were consistent between 3rd and 4th gen devices. Coil material did not significantly alter aerosol formation nor carbonyl yield when adjusted for wattage. This work shows that sub-ohm coils may not necessarily produce higher carbonyl yields even when they produce more aerosol mass. Furthermore, carbonyl formation is dynamic and not generalizable during the coil's lifetime. Finally, studies that compare data across different e-cigarette devices, coil age, and coil anatomy should account for the aerosol chemistry trends that depend on these parameters. [Description provided by NIOSH]
• Subjects:
  Aerosols Electrical Equipment And Supplies Occupational Health Safety
• Keywords:
  Aerosol Particles Carbonyls E-cigarettes Electronic Cigarettes Electronic Components
• ISSN:
  0893-228X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• Issue:
  10
• NIOSHTIC Number:
  nn:20069786
• Citation:
  Chem Res Toxicol 2023 Oct; 36(10):1599-1610
• Contact Point Address:
  Tran B. Nguyen, Department of Environmental Toxicology, University of California, Davis, Davis, California 95616, United States
• Email:
  tbn@ucdavis.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemical Research in Toxicology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c2577f8cad0828aa6a14bf27090565531959e1173acd246eb1f682dd457e70bf31e83fec087acb6460a0e4ad9d85392a79b8bdc8a797dc249d6451df13d2eab
• Download URL:
  https://stacks.cdc.gov/view/cdc/208142/cdc_208142_DS1.pdf
• File Type:
  [PDF - 4.21 MB ]