The Association of Air Pollution Exposure with Glucose and Lipid Levels: The Role of an Extreme Air Pollution Event Alongside 2 Decades of Moderate Exposure

Details

• Personal Author:
  Amini H ; Colicino E ; Just AC ; Knobel P ; McLaughlin MA ; Teitelbaum SL ; Yitshak Sade M
• Description:
  Extreme air pollution events and moderate exposure to fine particulate matter (PM2.5) are associated with increased cardiometabolic risk. The World Trade Center (WTC) Health Program general responder cohort includes responders to the WTC disaster. We investigated whether their exposure to this extreme air pollution event (2001) was associated with long-term metabolic outcomes, independently from the associations of intermediate-term PM2.5 exposure later in life (2004-2019). We included 22,447 cohort members with cholesterol (n = 96,155) and glucose (n = 81,599) laboratory results. Self-reported WTC exposure was derived from a questionnaire. PM2.5 exposure was derived from a satellite-based model. We observed an increase of 0.78 mg/dL (95% confidence interval (CI): 0.30, 1.26) in glucose and 0.67 mg/dL (95% CI: 1.00, 2.35) in cholesterol levels associated with an interquartile range increase in PM2.5 averaged 6 months before the study visit. Higher WTC-exposure categories were also associated with higher cholesterol (0.99 mg/dL, 95% CI: 0.30, 1.67, for intermediate exposure) and glucose (0.82 mg/dL, 95% CI: 0.22, 1.43, for high exposure) levels. Most associations were larger among people with diabetes. Extreme air pollution events and intermediate PM2.5 exposure have independent metabolic consequences. These exposures contributed to higher glucose and lipids levels among WTC responders, which may be translated into increased cardiovascular risk. [Description provided by NIOSH]
• Subjects:
  Air Pollution Blood Cohort Studies Dust Epidemiology Hematologic Diseases Lipids Occupational Health Particulate Matter Safety September 11 Terrorist Attacks

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• Keywords:
  Air Pollution Author Keywords: Cholesterol Blood Sugar Disorders Cohort Studies Diabetes Extreme Air Pollution Events Glucose Metabolic Disorders Particulate Dust Particulate Matter Particulates World Trade Center WTC

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-95
• Volume:
  193
• Issue:
  1
• NIOSHTIC Number:
  nn:20069379
• Citation:
  Am J Epidemiol 2024 Jan; 193(1):87-95
• Contact Point Address:
  Dr. Pablo Knobel, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029
• Email:
  pablo.knobel@mssm.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bfe9d88dbd8bdd27d1d184d6fe73e387cffc0346460c720e9e395ff8658193b7e414b8ccadab0f45cc6cf807f8479c779bb94e64901f06910c8a0672dadcc526
• Download URL:
  https://stacks.cdc.gov/view/cdc/207868/cdc_207868_DS1.pdf
• File Type:
  [PDF - 393.35 KB ]