Dry-Cleaning Chemicals and a Cluster of Parkinson’s Disease and Cancer: A Retrospective Investigation

Details

• Personal Author:
  Adams JL ; Auinger P ; Barbano R ; Braun MK ; Coffey M ; de Miranda BR ; Dorsey ER ; Goldman SM ; Hylton KL ; Kieburtz K ; Kinel D ; Lawrence BP ; Lettenberger SE ; Pawlik ME ; Schwarz HB ; Shaw CW ; Tanner CM ; Zafar M
• Description:
  Background: Environmental exposure to trichloroethylene (TCE), a carcinogenic dry-cleaning chemical, may be linked to Parkinson's disease (PD). Objective: The objective of this study was to determine whether PD and cancer were elevated among attorneys who worked near a contaminated site. Methods: We surveyed and evaluated attorneys with possible exposure and assessed a comparison group. Results: Seventy-nine of 82 attorneys (96.3%; mean [SD] age: 69.5 [11.4] years; 89.9% men) completed at least one phase of the study. For comparison, 75 lawyers (64.9 [10.2] years; 65.3% men) underwent clinical evaluations. Four (5.1%) of them who worked near the polluted site reported PD, more than expected based on age and sex (1.7%; P = 0.01) but not significantly higher than the comparison group (n = 1 [1.3%]; P = 0.37). Fifteen (19.0%), compared to four in the comparison group (5.3%; P = 0.049), had a TCE-related cancer. Conclusions: In a retrospective study, diagnoses of PD and TCE-related cancers appeared to be elevated among attorneys who worked next to a contaminated dry-cleaning site. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Pollution Neoplasms Occupational Health Safety Trichloroethylene
• Keywords:
  Author Keywords: Parkinson's Disease Cancer Rates Disease Hotspot Dry Cleaning Industry Environment Environmental Contamination Environmental Exposure Parkinsons Disease Perchloroethylene Tetrachloroethylene
• ISSN:
  1531-8257
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; California ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• Issue:
  3
• NIOSHTIC Number:
  nn:20069288
• Citation:
  Mov Disord 2024 Mar; 39(3):606-613
• Contact Point Address:
  Dr. E. Ray Dorsey, Department of Neurology, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420694, Rochester, NY 14642, USA
• Email:
  ray.dorsey@chet.rochester.edu
• CAS Registry Number:
  Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Movement Disorders
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f84bb5a11821b5d37e0ff1840c093bd33943642f665472b58c424b1425b7af688940faccf8b25bb8ea012feaa9b48def7f3bfa7424c12e42d034f33c9fdebf24
• Download URL:
  https://stacks.cdc.gov/view/cdc/207792/cdc_207792_DS1.pdf
• File Type:
  [PDF - 248.37 KB ]