Applied Force Alters Sensorineural and Peripheral Vascular Function in an Animal Model of Hand-Arm Vibration Syndrome (Dataset)

Details

• Personal Author:
  Boots T ; Chapman P ; Dong, Ren G. ; Krajnak, Kristine M. ; Warren C ; Waugh, Stacey ; Welcome, Daniel E. ; Xu S
• Description:
  Working with vibrating hand tools is associated with the development of hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms, finger blanching and changes in sensory function. Vibration plays a major role in the development of the symptoms that are characteristic of HAVS, however, the hands and fingers of worker using tools are also exposed to pressure applied as the workers grip tools. The pressure applied by gripping a tool might also affect blood flow and sensorineural function. Therefore, this study examined the effects of applied pressure [2 and 4 newtons (N)] on peripheral vascular and sensorineural function using a characterized rat tail model. The tails of rats were exposed to 0, 2 or 4N of applied force for 10 days. Blood flow (laser doppler) and sensitivity of the tail to pressure (Randall-Selitto pressure test) was measured on days 1, 5 and 10 of the exposure. The sensitivity of the tail nerves to electrical stimulation was measured on days 2 and 9. [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Safety
• Keywords:
  Force Hand-arm Vibration Syndrome Hand Tools HAVS Laboratory Animals Sensory Perceptual Processes
• DOI:
  https://doi.org/10.26616/NIOSHRD-1080-2024-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20069205
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1080-2024-0, 2024 Mar; :dataset
• Contact Point Address:
  Physical Effects Research Branch (PERB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Tel.: 303.285.6325
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2d51fb9ee6466af4a4fd6b5f9b430c55fa6fda4955f0fe0dc98d859907b3efb0f455f40e95774b145eb5cb8dc29b2ae3dff0f5b8ac1b248ce612e272270e64ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/207730/cdc_207730_DS1.pdf
• File Type:
  [PDF - 139.49 KB ]