Applied Force Alters Sensorineural and Peripheral Vascular Function in a Rat Model of Hand-Arm Vibration Syndrome

Details

• Personal Author:
  Boots T ; Chapman P ; Dong, Ren G. ; Krajnak, Kristine M. ; Warren C ; Waugh, Stacey ; Welcome, Daniel E. ; Xu X
• Description:
  Objective: This study described the effects of applied force (grip) on vascular and sensorineural function in an animal model of hand-arm vibration syndrome (HAVS). Methods: Rat tails were exposed to 0, 2, or 4 N of applied force 4 hr/d for 10 days. Blood flow and sensitivity to transcutaneous electrical stimulation and pressure were measured. Results: Applied force increased blood flow but reduced measures of arterial plasticity. Animals exposed to force tended to be more sensitive to 250-Hz electrical stimulation and pressure applied to the tail. Conclusions: Effects of applied force on blood flow and sensation are different than those of vibration. Studies examining co-exposures to force and vibration will provide data that can be used to determine how these factors affect risk of workers developing vascular and sensorineural dysfunction (ie, HAVS). Description provided by NIOSH
• Subjects:
  • Laboratories
  • Occupational Health
  • Safety
• Keywords:
  • Force
  • Laboratory animals
  • Sensory perceptual processes
  • Hand-arm vibration syndrome
  • HAVS
  • Author Keywords: hand-arm vibration syndrome
  • vascular
  • sensorineural
  • laser doppler
  • pressure
  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  93-104
• Volume:
  66
• Issue:
  2
• NIOSHTIC Number:
  nn:20068701
• Citation:
  J Occup Environ Med 2024 Feb; 66(2):93-104
• Contact Point Address:
  Kristine Krajnak, Ph.D., National Institute for Occupational Safety and Health (NIOSH), 1000 Fredrick Land, Morgantown WV 26508
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Download URL:
  https://stacks.cdc.gov/view/cdc/207288/cdc_207288_DS1.pdf
• File Type:
  [PDF - 553.50 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:599c9cfee78a4a1e78a5e05b10a28aa430a514d1bc32ed7df965ec927bf47fe5a7d1994571ed76cb29c16649b2f98417ffa3e12c2d21110077b77d6ff7381f0a