Applied Force Alters Sensorineural and Peripheral Vascular Function in a Rat Model of Hand-Arm Vibration Syndrome

Details

• Personal Author:
  Boots T ; Chapman P ; Dong, Ren G. ; Krajnak, Kristine M. ; Warren C ; Waugh, Stacey ; Welcome, Daniel E. ; Xu X
• Description:
  Objective: This study described the effects of applied force (grip) on vascular and sensorineural function in an animal model of hand-arm vibration syndrome (HAVS). Methods: Rat tails were exposed to 0, 2, or 4 N of applied force 4 hr/d for 10 days. Blood flow and sensitivity to transcutaneous electrical stimulation and pressure were measured. Results: Applied force increased blood flow but reduced measures of arterial plasticity. Animals exposed to force tended to be more sensitive to 250-Hz electrical stimulation and pressure applied to the tail. Conclusions: Effects of applied force on blood flow and sensation are different than those of vibration. Studies examining co-exposures to force and vibration will provide data that can be used to determine how these factors affect risk of workers developing vascular and sensorineural dysfunction (ie, HAVS). [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Safety
• Keywords:
  Author Keywords: Hand-arm Vibration Syndrome Force Hand-arm Vibration Syndrome HAVS Laboratory Animals Laser Doppler Pressure Sensorineural Sensory Perceptual Processes Vascular
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  93-104
• Volume:
  66
• Issue:
  2
• NIOSHTIC Number:
  nn:20068701
• Citation:
  J Occup Environ Med 2024 Feb; 66(2):93-104
• Contact Point Address:
  Kristine Krajnak, Ph.D., National Institute for Occupational Safety and Health (NIOSH), 1000 Fredrick Land, Morgantown WV 26508
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:599c9cfee78a4a1e78a5e05b10a28aa430a514d1bc32ed7df965ec927bf47fe5a7d1994571ed76cb29c16649b2f98417ffa3e12c2d21110077b77d6ff7381f0a
• Download URL:
  https://stacks.cdc.gov/view/cdc/207288/cdc_207288_DS1.pdf
• File Type:
  [PDF - 553.50 KB ]