Link Between Circadian Rhythm and Benign Prostatic Hyperplasia (BPH)/Lower Urinary Tract Symptoms (LUTS)

Details

• Personal Author:
  Cavanaugh D ; Figueiro M ; Kyprianou N ; Mohamed NE ; Tewari AK ; Urbanucci A
• Description:
  Background: Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health-related quality of life implores further investigation into its risk factors and strategies for effective management. Although the exact molecular mechanisms underlying pathophysiological onset of BPH are poorly defined, the current hypothesized contributors to BPH and lower urinary tract symptoms (LUTS) include aging, inflammation, metabolic syndrome, and hormonal changes. These processes are indirectly influenced by circadian rhythm disruption. In this article, we review the recent evidence on the potential association of light changes/circadian rhythm disruption and the onset of BPH and impact on treatment. Methods: A narrative literature review was conducted using PubMed and Google Scholar to identify supporting evidence. The articles referenced ranged from 1975 to 2023. Results: A clear relationship between BPH/LUTS and circadian rhythm disruption is yet to be established. However, common mediators influence both diseases, including proinflammatory states, metabolic syndrome, and hormonal regulation that can be asserted to circadian disruption. Some studies have identified a possible relationship between general LUTS and sleep disturbance, but little research has been done on the medical management of these diseases and how circadian rhythm disruption further affects treatment outcomes. Conclusions: There is evidence to implicate a relationship between BPH/LUTS and circadian rhythm disruptions. However, there is scarce literature on potential specific link in medical management of the disease and treatment outcomes with circadian rhythm disruption. Further study is warranted to provide BPH patients with insights into circadian rhythm directed appropriate interventions. [Description provided by NIOSH]
• Subjects:
  Aging Circadian Rhythm Men Occupational Health Safety Sleep
• Keywords:
  Author Keywords: Benign Prostate Growth Benign Prostatic Hyperplasia Circadian Rhythm Disruption Circadian Rhythms Hormone Activity Light Lower Urinary Tract Symptoms Metabolic Disorders Racial Disparities Risk Factors Therapeutic Management Urogenital System Disorders

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• ISSN:
  0270-4137
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  417-425
• Volume:
  84
• Issue:
  5
• NIOSHTIC Number:
  nn:20069101
• Citation:
  Prostate 2024 Apr; 84(5):417-425
• Contact Point Address:
  Natasha Kyprianou, MBBS, PhD and Mariana Figueiro, PhD, Tisch Cancer Institute at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA
• Email:
  Natasha.kyprianou@mountsinai.org
• Federal Fiscal Year:
  2024
• Performing Organization:
  Rensselaer Polytechnic Institute, Troy, New York
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  The Prostate
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:96ed1f6ec403991c1b450eb0ef02831ac3ed2f510633ce161231e76e7c6c600954f4c0b14d9f5901ea4e43111b0f1bc8250b5ddb6d07e1ebf6cb8bc9f02221dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/207643/cdc_207643_DS1.pdf
• File Type:
  [PDF - 651.86 KB ]