Lung Toxicity, Deposition, and Clearance of Thermal Spray Coating Particles with Different Metal Profiles After Inhalation in Rats

Details

• Personal Author:
  Afshari AA ; Andrews R ; Antonini JM ; Cumpston JB ; Cumpston JL ; Erdely A ; Friend S ; Kodali V ; Lee EG ; Leonard HD ; Leonard, Stephen S. ; McKinney W ; Meighan TG ; Zeidler-Erdely PC
• Description:
  Thermal spray coating is a process in which molten metal is sprayed onto a surface. Little is known about the health effects associated with these aerosols. Sprague-Dawley rats were exposed to aerosols (25 mg/m3 × 4 hr/d × 4 d) generated during thermal spray coating using different consumables [i.e. stainless-steel wire (PMET731), Ni-based wire (PMET885), Zn-based wire (PMET540)]. Control animals received air. Bronchoalveolar lavage was performed at 4 and 30 d post-exposure to assess lung toxicity. The particles were chain-like agglomerates and similar in size (310-378 nm). Inhalation of PMET885 aerosol caused a significant increase in lung injury and inflammation at both time points. Inhalation of PMET540 aerosol caused a slight but significant increase in lung toxicity at 4 but not 30 d. Exposure to PMET731 aerosol had no effect on lung toxicity. Overall, the lung responses were in the order: PMET885"PMET540 >PMT731. Following a shorter exposure (25 mg/m3 × 4 h/d × 1d), lung burdens of metals from the different aerosols were determined by ICP-AES at 0, 1, 4 and 30 d post-exposure. Zn was cleared from the lungs at the fastest rate with complete clearance by 4 d post-exposure. Ni, Cr, and Mn had similar rates of clearance as nearly half of the deposited metal was cleared by 4 d. A small but significant percentage of each of these metals persisted in the lungs at 30 d. The pulmonary clearance of Fe was difficult to assess because of inherently high levels of Fe in control lungs. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Lung Occupational Health Particulate Matter Respiratory System Safety Toxicology
• Keywords:
  Animal Studies Author Keywords: Thermal Spray Coating Cellular Effects Inhalation Lung Tissue Lung Toxicity Metal Oxides Metals Nanotoxicology Particulates Protective Coatings Sprays

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  10
• NIOSHTIC Number:
  nn:20069056
• Citation:
  Nanotoxicology 2023 Dec; 17(10):669-686
• Contact Point Address:
  James Antonini, Health Effects Laboratory Division, Centers for Disease Control & Prevention, National Institute for Occupational Safety and Health, 1000 Frederick Lane (Mailstop 2015), Morgantown, WV 26508, USA
• Email:
  JGA6@cdc.gov
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ee430bdb0a7893615ffd269b4864f6936d13307d2b6a01c5c0782bbc68609260deb51718b75ee5361f9edf090d5f8e4c875f0c4e53ae562ade039ebe8d12d88d
• Download URL:
  https://stacks.cdc.gov/view/cdc/207605/cdc_207605_DS1.pdf
• File Type:
  [PDF - 2.68 MB ]