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Effects of Nanoparticles on the Pulmonary Vasculature



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  • Personal Author:
  • Description:
    Nanoparticles (NPs) are ubiquitous in the atmosphere and arise from both natural and anthropogenic sources. Increased concern over exposure to NPs has developed due to epidemiological findings that support the hypothesis that inhalation of these materials is associated with the induction and exacerbation of cardiovascular disease (CVD) and related CVD risk factors. These associations have spurred the scientific community to try to understand the mechanisms of the cardiovascular responses to inhaled ultrafine particles and NPs. As a result, several plausible mechanistic hypotheses for the development of cardiovascular effects within the pulmonary vasculature have been proposed. Involvement of the pulmonary vascular bed in particulate­induced health effects is plausible due to its location, structure, function, and cellular makeup and its involvement in the inflammatory and oxidative response to inhaled agents. Inhalation of NPs may induce or exacerbate preexisting cardiovascular conditions through inflammatory or oxidative stress pathways arising from the pulmonary epithelium or vascular endothelium and result in cellular damage and subsequent loss of function. Epidemiological studies and studies using human, animal, and cellular systems have been done to elucidate the key physical, chemical, spatial and temporal characteristics of NP-induced health effects and are summarized in a recent review (Mills et al., 2007). This chapter provides an anatomical and physiologic framework for further discussion of mechanisms of pulmonary vascular impacts of NPs in the context of major cellular players within the pulmonary vasculature. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISBN:
    9780470433539
  • Publisher:
    John Wiley & Sons, Inc
  • Document Type:
    Text
  • Funding:
    Cooperative Agreement
  • Genre:
    Book
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    319-350
  • NIOSHTIC Number:
    nn:20068966
  • Citation:
    Cardiovascular effects of inhaled ultrafine and nanosized particles. Cassee FR, Mills NL, Newby D, eds. Hoboken, NJ: John Wiley & Sons, 2011 Feb; :319-350
  • Editor(s):
    Cassee FR; Mills NL; Newby D
  • Federal Fiscal Year:
    2011
  • NORA Priority Area:
    Agriculture, Forestry and Fishing
  • Performing Organization:
    University of California - Davis
  • Peer Reviewed:
    False
  • Start Date:
    20010930
  • Source Full Name:
    Cardiovascular effects of inhaled ultrafine and nanosized particles
  • End Date:
    20270929
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:e8e2d6767e77a91dae30a47cc2208ab4a73b49b663cc547671b524c993a67e60832c6fd989cab13bb49477384bbfd1bdfe5a0b9ea79ef08b2758ced67c0f04d5
  • Download URL:
  • File Type:
    Filetype[PDF - 8.11 MB ]
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