Engineered Nanoparticle Exposure and Cardiovascular Effects: The Role of a Neuronal-Regulated Pathway

Details

• Personal Author:
  Castranova, Vincent ; Kan, H. ; Pan, D.
• Description:
  Human and animal studies have confirmed that inhalation of particles from ambient air or occupational settings not only causes pathophysiological changes in the respiratory system, but causes cardiovascular effects as well. At an equal mass lung burden, nanoparticles are more potent in causing systemic microvascular dysfunction than fine particles of similar composition. Thus, accumulated evidence from animal studies has led to heightened concerns about the potential short- and long-term deleterious effects of inhalation of engineered nanoparticles on the cardiovascular system. This review highlights the new observations from animal studies, which document the adverse effects of pulmonary exposure to engineered nanoparticles on the cardiovascular system and elucidate the potential mechanisms involved in regulation of cardiovascular function, in particular, how the neuronal system plays a role and reacts to pulmonary nanoparticle exposure based on both in vivo and in vitro studies. In addition, this review also discusses the possible influence of altered autonomic nervous activity on preexisting cardiovascular conditions. Whether engineered nanoparticle exposure serves as a risk factor in the development of cardiovascular diseases warrants further investigation. [Description provided by NIOSH]
• Subjects:
  Animals Cardiovascular Diseases Cardiovascular System Lung Occupational Exposure Occupational Health Respiratory System Safety
• Keywords:
  Author Keywords: Engineered Nanoparticles; Occupation Exposure; Autonomic Activity; Cardiovascular Diseases Nanotechnology; Nanoparticles; Inhalation; Inhalation Studies; In Vitro Studies; In Vivo Studies; Animal Studies; Cardiovascular Function; Cardiovascular System; Health Effects; Biological Effects; Lung Burden; Cardiovascular System Disorders; Nervous System; Nervous System Function; Pulmonary System; Autonomic Nervous System; Occupational Exposure;
• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 pdf pages
• Volume:
  30
• NIOSHTIC Number:
  nn:20054786
• Citation:
  Inhal Toxicol 2018 Aug; 30(9-10):335-342
• Contact Point Address:
  Hong Kan, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  hvn4@cdc.gov
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5840def49ac07be111b2bb0aa14485fde3f821f85a8be2a0b792930961752e5a9262efd26bb5bd5723a1240e58a9cb530e3cc07876966124837347c706129fa1
• Download URL:
  https://stacks.cdc.gov/view/cdc/231554/cdc_231554_DS1.pdf
• File Type:
  [PDF - 2.87 MB ]