Guidance on Mitigating the Risk of Transmitting Respiratory Infections During Nebulization by the COPD Foundation Nebulizer Consortium

Details

• Personal Author:
  Ari A ; Barjaktarevic IZ ; Biney IN ; Cambridge L ; Carlin B ; Christiani, David C. ; Cochran L ; Dailey PA ; Dhand R ; Drummond MB ; Johnson K ; Kealing D ; Kuehl PJ ; Li J ; Mahler DA ; Mannino, David M. ; Martinez S ; Ohar J ; Radonovich LJ ; Sood A ; Suggett J ; Tal-Singer R ; Tashkin D ; Yates J
• Description:
  Background: Nebulizers are used commonly for inhaled drug delivery. Because they deliver medication through aerosol generation, clarification is needed on what constitutes safe aerosol delivery in infectious respiratory disease settings. The COVID-19 pandemic highlighted the importance of understanding the safety and potential risks of aerosol-generating procedures. However, evidence supporting the increased risk of disease transmission with nebulized treatments is inconclusive, and inconsistent guidelines and differing opinions have left uncertainty regarding their use. Many clinicians opt for alternative devices, but this practice could impact outcomes negatively, especially for patients who may not derive full treatment benefit from handheld inhalers. Therefore, it is prudent to develop strategies that can be used during nebulized treatment to minimize the emission of fugitive aerosols, these comprising bioaerosols exhaled by infected individuals and medical aerosols generated by the device that also may be contaminated. This is particularly relevant for patient care in the context of a highly transmissible virus. Research Question: How can potential risks of infections during nebulization be mitigated? Study Design and Methods: The COPD Foundation Nebulizer Consortium (CNC) was formed in 2020 to address uncertainties surrounding administration of nebulized medication. The CNC is an international, multidisciplinary collaboration of patient advocates, pulmonary physicians, critical care physicians, respiratory therapists, clinical scientists, and pharmacists from research centers, medical centers, professional societies, industry, and government agencies. The CNC developed this expert guidance to inform the safe use of nebulized therapies for patients and providers and to answer key questions surrounding medication delivery with nebulizers during pandemics or when exposure to common respiratory pathogens is anticipated. Results: CNC members reviewed literature and guidelines regarding nebulization and developed two sets of guidance statements: one for the health care setting and one for the home environment. Interpretation: Future studies need to explore the risk of disease transmission with fugitive aerosols associated with different nebulizer types in real patient care situations and to evaluate the effectiveness of mitigation strategies. [Description provided by NIOSH]
• Subjects:
  Aerosols Communicable Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Aerosol-generating Procedure Aerosol Dispersion Aerosol Generators Aerosol Particles Author Keywords: Aerosol Bioaerosols Clinical Techniques COVID-19 Disease Transmission Fugitive Aerosols Nebulizer Occupational Exposure Recommendations Respiratory Diseases

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• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Florida ; Illinois ; Massachusetts ; New Hampshire ; New Mexico ; North Carolina ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Pennsylvania ; Tennessee ; Texas ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• Issue:
  3
• NIOSHTIC Number:
  nn:20068802
• Citation:
  Chest 2024 Mar; 165(3):653-668
• Contact Point Address:
  Isaac N. Biney, MD, University Pulmonary and Critical Care, The University of Tennessee Graduate School of Medicine, 1940 Alcoa Hwy, Building E, Suite 210, Knoxville, TN, 37920, USA
• Email:
  IBiney@utmck.edu
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  Chest
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3812833c71b89f8c15c04f46f09c165227a0a1d24f3071234b2f503277339e383b6d33b8399f7b98c2c3872a9ad01c2abe4eee150c13d8bc0b63556404007f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/207377/cdc_207377_DS1.pdf
• File Type:
  [PDF - 837.15 KB ]