Incidence of Mild Cognitive Impairment in World Trade Center Responders: Long-Term Consequences of Re-Experiencing the Events on 9/11/2001

Details

• Personal Author:
  Bromet EJ ; Carr M ; Clouston SAP ; Deri Y ; Diminich ED ; Gandy S ; Kotov R ; Luft BJ ; Pietrzak RH ; Richards M ; Sano M ; Spiro A III ; Yang X
• Description:
  Objective: This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods: Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional-hazards regression. Results: Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow-up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein-e4 carriers. Conclusions: PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC-exposed responders. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: World Trade Center Disaster Cognitive Function Cohort Studies Longitudinal Study Mental Health Mild Cognitive Impairment Post-traumatic Stress Disorder Posttraumatic Stress PTSD World Trade Center WTC

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• ISSN:
  2352-8729
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20068507
• Citation:
  Alzheimers Dement Diagn Assess Dis Monit 2019 Dec; 11(1):628-636
• Contact Point Address:
  Sean A. P. Clouston, Department of Family, Population, and Preventive Medicine, Program in Public Health, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa7d59673293c83b3fbc70436944ab8342e9090fd5a15e3d2f5fafee09a6086f1994599eebe8046b9cc6c28a7455c64c20e86b82787c6b4d9d714955b8cc12af
• Download URL:
  https://stacks.cdc.gov/view/cdc/207123/cdc_207123_DS1.pdf
• File Type:
  [PDF - 429.75 KB ]