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Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011
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Jun 2013
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Source: Emerg Infect Dis 19(6):932-937
[PDF-375.33 KB]
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Alternative Title:Emerg Infect Dis
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Description:Before introduction of Haemophilus influenzae type b (Hib) vaccines, rates of Hib disease in Alaska's indigenous people were among the highest in the world Vaccination reduced rates dramatically; however, invasive H influenzae type a (Hia) disease has emerged Cases of invasive disease were identified through Alaska statewide surveillance during 1983-2011 Of 866 isolates analyzed for serotype, 32 (4%) were Hia No Hia disease was identified before 2002; 32 cases occurred during 2002-2011 (p<0001) Median age of case-patients was 07 years; 3 infants died Incidence of Hia infection (2002-2011) among children <5 years was 54/100,000; 27 cases occurred in Alaska Native children (18/100,000) versus 2 cases in non-Native children (05/100,000) (risk ratio = 36, p<0001) From 12/2009 to 12/2011, 15 cases of Hia disease occurred in southwestern Alaska (in children <5 years, rate = 204/100,000) Since introduction of the Hib conjugate vaccine, Hia infection has become a major invasive bacterial disease in Alaska Native children
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Volume:19
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Issue:6
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