Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1906.121805
Personal Author:
Bruce, Michael G. ; Zulz, Tammy ; DeByle, Carolynn ; Singleton, Ros ; Hurlburt, Debby ; ... More +
Bruce, Michael G. ; Zulz, Tammy ; DeByle, Carolynn ; Singleton, Ros ; Hurlburt, Debby ; Bruden, Dana ; Rudolph, Karen ; Hennessy, Thomas ; Klejka, Joseph ; Wenger, Jay D. ; Less -
Description:
Before introduction of Haemophilus influenzae type b (Hib) vaccines, rates of Hib disease in Alaska's indigenous people were among the highest in the world. Vaccination reduced rates dramatically; however, invasive H. influenzae type a (Hia) disease has emerged. Cases of invasive disease were identified through Alaska statewide surveillance during 1983-2011. Of 866 isolates analyzed for serotype, 32 (4%) were Hia. No Hia disease was identified before 2002; 32 cases occurred during 2002-2011 (p<0.001). Median age of case-patients was 0.7 years; 3 infants died. Incidence of Hia infection (2002-2011) among children <5 years was 5.4/100,000; 27 cases occurred in Alaska Native children (18/100,000) versus 2 cases in non-Native children (0.5/100,000) (risk ratio = 36, p<0.001). From 12/2009 to 12/2011, 15 cases of Hia disease occurred in southwestern Alaska (in children <5 years, rate = 204/100,000). Since introduction of the Hib conjugate vaccine, Hia infection has become a major invasive bacterial disease in Alaska Native children.
Subject:
[+]
Adolescent
Adult
Alaskan Natives
Child
Child, Preschool
Disease Outbreaks
Geography
Haemophilus Infections
History, 20th Century
History, 21st Century
Humans
Incidence
Infant
Middle Aged
Multilocus Sequence Typing
Public Health Surveillance
Research
Serotyping
Young Adult

Source:
Emerg Infect Dis. 19(6):932-937. ;
Document Type:
Journal Article ;
Place as Subject:
Alaska ;
Collection(s):
Arctic Investigations Program
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3f96ae0d9ddab2f06edcbc7de32cc6d5ce5dd3f40b5674249111fc84f114ce33
File Type:

Supporting Files

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  	12-1805-F2.gif	gif
  	12-1805-F2.jpg	jpeg
  	12-1805.nxml	txt
  	license.txt	txt

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