Identifying Metabolic Syndrome in African American Children Using Fasting HOMA-IR in Place of Glucose

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Sharma, Sushma ; Lustig, Robert H. ; Fleming, Sharon E.
• Description:
  Introduction
  
  Metabolic syndrome (MetS) is increasing among young people. We compared the use of homeostasis model assessment of insulin resistance (HOMA-IR) with the use of fasting blood glucose to identify MetS in African American children.
  
  Methods
  
  We performed a cross-sectional analysis of data from a sample of 105 children (45 boys, 60 girls) aged 9 to 13 years with body mass indexes at or above the 85th percentile for age and sex. Waist circumference, blood pressure, and fasting levels of blood glucose, insulin, triglycerides, and high-density lipoprotein cholesterol were measured.
  
  Results
  
  We found that HOMA-IR is a stronger indicator of MetS in children than blood glucose. Using HOMA-IR as 1 of the 5 components, we found a 38% prevalence of MetS in this sample of African American children and the proportion of false negatives decreased from 94% with blood glucose alone to 13% with HOMA-IR. The prevalence of MetS was higher in obese than overweight children and higher among girls than boys.
  
  Conclusion
  
  Using HOMA-IR was preferred to fasting blood glucose because insulin resistance was more significantly interrelated with the other 4 MetS components.
  
  
• Subjects:
  Adolescent Black Or African American Blood Glucose Blood Pressure Child Cross-Sectional Studies Fasting Female Homeostasis Humans Insulin Resistance Male Metabolic Syndrome X Obesity Overweight Prevalence Urban Population

  More +
• Source:
  Prev Chronic Dis. 2011; 8(3).
• ISSN:
  1545-1151
• Document Type:
  Journal Article
• Place as Subject:
  California
• Location:
  North America
• Volume:
  8
• Issue:
  3
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:0683421e451fb86fcd42722b34e68da5644d12e8415859898ad3c1e565f755ea7819a6dc4c9aec08a615ecca96dcc8b903433663042ceba2f4eb5e317b27993b
• Download URL:
  https://stacks.cdc.gov/view/cdc/20582/cdc_20582_DS1.pdf
• File Type:
  [PDF - 603.01 KB ]