Toxigenic molds in water-damaged buildings: dechlorogriseofulvins from Memnoniella echinata

Details

• Personal Author:
  Dearborn DG ; Etzel RA ; Hintikka L ; Jarvis BB ; Jiang J ; Nikulin M ; Parikka P ; Sorenson WG ; Wang S ; Zhou Y
• Description:
  A cluster of cases of pulmonary hemosiderosis was reported in infants in Cleveland, Ohio, which resulted in an investigation of dampness in the homes of these infants as a common factor. In each home, varying levels of contamination by Stachybotrys-atra was found. Two isolates of Memnoniella-echinata were also noted whose cultures proved cytotoxic against fetal feline lung cells. One isolate was grown on rice for 30 days, extracted and chromatographed providing a number of fractions several of which were highly cytotoxic. Two of the fractions yielded trichodermol (2198938) and trichodermin (4682502). A low cytotoxic fraction yielded dechlorogriseofulvin and epidechlorogriseofulvin. The production of such a wide variety of cytotoxins and immunosuppressants contributes significantly to the toxicity of these organisms. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Epidemiology Fungi Infant, Newborn Lung Diseases Microbiology Mycoses Occupational Health Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Cytotoxins Environmental-exposure Lung-disease Microorganisms Mycotoxins Neonates NIOSH-Author Respiratory-system-disorders Risk-factors
• ISSN:
  0163-3864
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  6
• NIOSHTIC Number:
  nn:00232642
• Citation:
  J Nat Prod 1996 Jun; 59(6):553-554
• CAS Registry Number:
  Trichodermin (CAS RN 4682-50-2) ; Trichodermol (CAS RN 2198-93-8)
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Natural Products
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:70fcd76990696197bac9520c8753f1c1c662d9559e4372666cc6407cb95e7b2fc2a5ce14205b3e022afd229d54951d58f53c95bf7637b07f209789b8b6fa9d6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/205803/cdc_205803_DS1.pdf
• File Type:
  [PDF - 78.54 KB ]