The role of superoxide radical in chromium(VI)-generated hydroxyl radical: the Cr(VI) Haber-Weiss cycle

Details

• Personal Author:
  Dalal NS ; Shi X
• Description:
  The role of the superoxide radical (O2) in the cellular injury caused by exposure to chromium (7440473) (Cr) was investigated. Cr(VI) catalyzed the formation of the hydroxyl radical from superoxide by a Haber-Weiss type of cycle. Electron spin resonance and spin trapping techniques were used to monitor the formation of Cr(V) from the reduction of Cr(VI) by the superoxide radical and the subsequent generation of the hydroxyl radical by reaction of the Cr(V) species with hydrogen-peroxide. This work provided the first experimental evidence that Cr(VI) is capable of catalyzing a Haber- Weiss cycle to generate hydroxyl radicals; further, it offered a clue as to why molecular oxygen plays a fundamental role in the genotoxic reactions associated with exposure to Cr(VI) containing compounds. The usefulness of antioxidants as antagonists toward Cr(VI) related genotoxicity was implied. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chromium Cytotoxins Free Radicals Occupational Health Safety
• Keywords:
  Biotransformation Cell-damage Cytotoxic-effects Free-radicals Genotoxic-effects Hexavalent-chromium-compounds NIOSH-Cooperative-Agreement NIOSH-Publication
• ISSN:
  0003-9861
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  323-327
• Volume:
  292
• Issue:
  1
• NIOSHTIC Number:
  nn:00205542
• Citation:
  Arch Biochem Biophys 1992 Jan; 292(1):323-327
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Center to Protect Workers' Rights
• Peer Reviewed:
  True
• Start Date:
  19900928
• Source Full Name:
  Archives of Biochemistry and Biophysics
• End Date:
  19970515
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8c9e7ad974e59691622af19f1905ba9680d4f2ae4b83e8aca73c2ccb009dead269fe5d2d7eb47dcb6ddf862c7f8eccd1f02ea5979d78d7eda903b842d4249867
• Download URL:
  https://stacks.cdc.gov/view/cdc/205775/cdc_205775_DS1.pdf
• File Type:
  [PDF - 489.42 KB ]