In Vivo Reduction of Chromium (VI) and Its Related Free Radical Generation

Details

• Personal Author:
  Liu KJ ; Shi X
• Description:
  Chromium (VI) compounds are widely recognized as human carcinogens. Extensive studies in vitro and in model systems indicate that the reactive intermediate, Cr (V), generated by cellular reduction of Cr (VI), is likely the candidate for the ultimate carcinogenic form of chromium compounds. Here we review our current understanding of the in vivo reduction of Cr (VI) and its related free radical generation. Our results demonstrate that Cr (V) is indeed generated from the reduction of Cr (VI) in vivo, and that Cr (V) thus formed can mediate the generation of free radicals. Cr (V) and its related free radicals are very likely to be involved in the mechanism of Cr (VI)-induced toxicity and carcinogenesis. These studies also illustrate that in vivo EPR spectroscopy and magnetic resonance imaging can be very useful and powerful tools for studying paramagnetic metal ions in chemical and biochemical reactions occurring in intact animals. [Description provided by NIOSH]
• Subjects:
  Biochemistry Carcinogens Chromium Free Radicals Occupational Health Safety
• Keywords:
  Author Keywords: EPR Biochemical-analysis Carcinogenesis Carcinogenicity Chromium Chromium-compounds Free-radical-generation Free-radicals Free Radical In-vitro-studies In-vivo-studies Metallic-ions Models MRI Reactive Oxygen Species

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  41-47
• Volume:
  222
• Issue:
  1
• NIOSHTIC Number:
  nn:20021795
• Citation:
  Mol Cell Biochem 2001 Jun; 222(1-2):41-47
• Email:
  jliu@unm.edu
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3366be1aed8e50ecc3ce6b95c8df897113e0d4e5923d4193e1138950d6d9a2b2ac3e260b9e265d4ce52808d9d3d931f1b21366ac6a2e2aae87874e75385c6da4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198900/cdc_198900_DS1.pdf
• File Type:
  [PDF - 141.09 KB ]