Synergistic interaction of nitrogen dioxide and ozone on rat lungs: acute responses

Details

• Personal Author:
  Gelzleichter TR ; Last JA ; Witschi H
• Description:
  The synergistic interaction between nitrogen-dioxide (10102440) and ozone (10028156) was investigated in Sprague-Dawley-rats. Rats were exposed for 6 hours per day for 3 days to ozone (0.2 to 0.8 parts per million (ppm)), nitrogen-dioxide (3.6 to 14.4ppm), or combinations of both oxidant air pollutants. Responses were quantified by changes in total protein content of lung lavage supernatants or by alterations in the content of specific cell types in lavage pellets. Results revealed a concentration dependent synergistic response upon combined exposure. Concurrent exposure was necessary to elicit positive interaction which is a greater than additive response. No positive interactions were seen when rats were exposed sequentially to ozone or nitrogen-dioxide. Given the apparent disappearance rates of ozone during combined exposure, predicted outcomes were modeled on the assumption that ozone and nitrogen-dioxide were reacting in the chambers to form nitrogen-pentoxide. The authors conclude that synergistic toxicologic interactions between ozone and nitrogen-dioxide are found only at concentrations much higher than would be found in environmental or occupational settings. The potential for chronic toxicological responses with levels below those causing acute responses requires further investigation. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Pollution Hazardous Substances Laboratories Lung Nitrogen Oxides Occupational Health Respiratory System Safety
• Keywords:
  Combustion-gases Environmental-pollution Laboratory-animals Lung-cells Nitrogen-oxides Protein-chemistry Synergism Toxic-gases
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• Volume:
  116
• Issue:
  1
• NIOSHTIC Number:
  nn:00210122
• Citation:
  Toxicol Appl Pharmacol 1992 Sep; 116(1):1-9
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  1992
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a1448d6e152db06aabe736939244e565a80a15a26dc4256f5675ebb47a658cc2ee49efc1a28a78c851c5de454179d234339ad3f238a38d99e7bb5ba55c0eb3cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/205667/cdc_205667_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]