Supramicron-sized particle clearance from alveoli: route and kinetics

Details

• Personal Author:
  Bergofsky EH ; Foster WM ; Halpern JG ; Langenback EG ; Bergofsky EH ; Foster WM ; Halpern JG ; Langenback EG
• Description:
  The clearance routes and kinetics of an inert insoluble carbonized polystyrene particle of supramicron size tagged with cobalt-57 (13981505) was examined in the adult unanesthetized sheep. The investigation was conducted to demonstrate, in a large animal comparable to a human, the kinetics of long term supramicron sized particle clearance from the alveoli, the routes of clearance followed by these particles exiting the alveoli, and some of the physiological characteristics of the later phase of alveoli clearance. The rate of particle clearance revealed a three exponential function, comprising a rapid initial phase in the first 44 hours of clearance for tracheobronchial deposition followed by a slower phase of mostly alveolar clearance in the next 30 days and a final phase of very slow relatively pure alveolar clearance. This supramicron sized particle cleared from alveoli predominantly via the mucociliary escalator of the tracheobronchial tree. Particle and macrophage recovery rates suggested a sequestered state for alveolar deposited particles which may partly account for their slow clearance rates. Macrophages engulfing these particles at low particle burdens traveled normally in only one direction, that is, from interstitium to alveolus and then to the mucociliary escalator. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Laboratories Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Airborne Particles Alveolar Cells Inhalation Studies Laboratory Animals Lung Cells NIOSH Grant NIOSH Publication Particulates Respiratory System Disorders
• ISSN:
  8750-7587
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  69
• Issue:
  4
• NIOSHTIC Number:
  nn:00197986
• Citation:
  J Appl Physiol 1990 Oct; 69(4):1302-1308
• Contact Point Address:
  Medicine Suny at Stony Brook Hsc, T-17, Room 040, Stony Brook, NY 11794
• CAS Registry Number:
  Cobalt-57 (CAS RN 13981-50-5) ; Cobalt-57 (CAS RN 13981-50-5)
• Federal Fiscal Year:
  1991
• Performing Organization:
  State University New York Stony Brook, Stony Brook, New York
• Peer Reviewed:
  True
• Start Date:
  19870101
• Source Full Name:
  Journal of Applied Physiology
• End Date:
  19960131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed60c9ad03fa5b7d228f80a5335f8458d40418c5a57d37057c2168045e08fdec00fdf8de00fdec5fb1fe948cd88946ea28a737481f07b2dfaac2d58732c0644b
• Download URL:
  https://stacks.cdc.gov/view/cdc/205652/cdc_205652_DS1.pdf
• File Type:
  [PDF - 2.36 MB ]