Serum levels of PCDDs and PCDFs among workers exposed to 2,3,7,8-TCDD contaminated chemicals

Details

• Personal Author:
  Connally LB ; Fingerhut, Marilyn A. ; Patterson DG Jr. ; Piacitelli, Laurie A. ; Sweeney, Marie H. ; Tompkins B ; Turner, Wayman E. ; Wille KK
• Description:
  The serum levels of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) were determined in workers occupationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) and in nonexposed referents. Serum samples were collected during a NIOSH medical survey from 280 workers exposed to TCDD and 99 nonexposed referents. Determination and lipid adjustments of PCDD and PCDF levels were conducted in both study groups. Workers exhibited a significant elevation of serum TCDD, 2,3,4,7,8-PnCDF, and 1,2,3,4,7,8-HxCDF compared to nonexposed referents. Detectable samples for six furan isomers were found for only 10 to 40% of the samples analyzed. The levels of TCDD in the workers of this study were among the highest concentrations reported in the literature. TCDD levels in nonexposed subjects were consistent with the levels that have been reported for other nonexposed populations. [Description provided by NIOSH]
• Subjects:
  Clinical Laboratory Techniques Furans Occupational Exposure Occupational Health Safety
• Keywords:
  Clinical-chemistry Humans NIOSH-Author Occupational-exposure Occupational-hazards Polychlorinated-aromatic-hydrocarbons
• ISSN:
  0045-6535
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  251-254
• Volume:
  25
• Issue:
  1
• NIOSHTIC Number:
  nn:00210167
• Citation:
  Chemosphere 1992 Jul; 25(1-2):251-254
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Chemosphere
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d1626f33700f32574e864e38181fed2eb8305de0c9e1a99491faf5e6b2f804eb8660ced3206ca3fe4f4306466ab70fbd358f2f0307488f8acd2d347656db31d5
• Download URL:
  https://stacks.cdc.gov/view/cdc/205583/cdc_205583_DS1.pdf
• File Type:
  [PDF - 159.36 KB ]