Serum growth factors and oncoproteins in firefighters

Details

• Personal Author:
  Brandt-Rauf P ; Ford J ; Friedman-Jimenez G ; Garibaldi K ; Luo C ; Markowitz S ; Niman H ; Smith S
• Description:
  A study of serum growth factors and oncoproteins in firefighters was conducted to determine if serum growth factors or oncoproteins could serve as biomarkers for the development of cancer or nonmalignant respiratory disease. The cohort of 33 New York City firefighters, mean age 55 years, was selected from among participants in a medical surveillance program. The comparisons consisted of 16 healthy medical center volunteers, mean age 54 years. Blood samples were collected and assayed for beta transforming growth factor (bTGF), platelet derived growth factor (PDGF), and the oncogene proteins ras, fes, myc, myb, mos, src, and int using an immunoblotting technique. Medical and occupational histories of the subjects were reviewed. No positive bands for PDGF, ras, fes, myc, myb, mos, src, or int were found in any of the serum samples. Fourteen firefighters were positive for bTGF, but none of the comparisons were. The bTGF positive and negative firefighters were similar with regard to age and years of employment in firefighting. Compared to the seronegative firefighters, bTGF positive firefighters were slightly more likely to have abnormal chest X-rays, a prior history of asbestos (1332214) exposure, fewer pulmonary complaints, and to be nonsmokers. None of the differences were statistically significant. The authors conclude that bGTF may be related to pathological processes induced by firefighting exposure. It may be suitable for monitoring pathological changes related to nonmalignant respiratory disease or cancer in firefighters and other exposed populations. [Description provided by NIOSH]
• Subjects:
  Biochemistry Epidemiology Firefighters Growth Neoplasms Occupational Exposure Occupational Health Safety Smokers Tobacco Products
• Keywords:
  Biochemical-indicators Blood-serum Cancer Cigarette-smoking Firemen Growth-factors Malignant-neoplasms NIOSH-Grant NIOSH-Publication Occupational-exposure Occupational-medicine

  More +
• ISSN:
  0962-7480
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-42
• Volume:
  42
• Issue:
  1
• NIOSHTIC Number:
  nn:00206744
• Citation:
  Occup Med 1992 Feb; 42(1):39-42
• Contact Point Address:
  Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1992
• Performing Organization:
  Columbia University New York, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19890715
• Source Full Name:
  Occupational Medicine
• End Date:
  19930114
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:11a25b89c96ed05d13bdb1c3836ee154bbd9ed695fae739c9fb44950fff4fd34ca50c2f1792ba88e80fb5ef5905bd82f99abc28d574293010f9ec2df304bb57a
• Download URL:
  https://stacks.cdc.gov/view/cdc/205582/cdc_205582_DS1.pdf
• File Type:
  [PDF - 468.01 KB ]