Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates

Details

• Personal Author:
  Crumbliss AL ; Ghio AJ ; Hatch GE ; Hoidal JR ; Kennedy TP ; Whorton AR
• Description:
  The pathogenesis of the pulmonary damage caused by the inhalation of silicates was studied by examining the effects of iron (7439896) complexation on oxidant generation in-vitro and in-vivo. The mineral dusts studied included silica (14808607), crocidolite (12001284), kaolinite (1318747), and talc (14807966). Significant concentrations of surface iron were seen in all of the mineral oxide dusts and all were able to further adsorb more iron in quantities greater than rutile, a control substance, when examine in-vitro. Intratracheal infusion of Sprague-Dawley-rats with 20 milligrams of one of the mineral dusts, followed by the examination of lung tissue 96 hours later, demonstrated that all dusts had adsorbed iron onto their surfaces in greater amounts than rutile. As the concentration of surface complexed iron increased, an increase in thiobarbituric- acid reactive products of deoxyribose was seen. Oxidant generation was increased upon iron loading of the mineral oxide surface. The chemiluminescent response of alveolar macrophages indicative of a respiratory burst and the release of leukotriene-B4 were induced with the addition of wetted silica, crocidolite, kaoline, and talc; these responses were enhanced using iron loaded dusts. A cellular influx and an increase in bronchoalveolar protein was seen in rats following injection of wetted silica. Iron loading the silica further increased these changes. The authors conclude that the pulmonary disease caused by silicate exposure may in part be due to the surface complexation of iron. [Description provided by NIOSH]
• Subjects:
  Asbestos Dust Ferrous Compounds Hazardous Substances Inorganic Chemicals Laboratories Lung Diseases Occupational Health Respiratory Tract Diseases Safety Silicon Compounds Silicon Dioxide

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• Keywords:
  Asbestos Author Keywords: Iron Chelates Free Radicals Iron-compounds Laboratory-animals Lung-disease Mineral-dusts Molecular-biology NIOSH-Grant NIOSH-Publication Pathogenicity Pulmonary-system-disorders Silica Silicon-compounds Toxic-effects

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• ISSN:
  1040-0605
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 4 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  263
• Issue:
  5
• NIOSHTIC Number:
  nn:00211599
• Citation:
  Am J Physiol Lung Cell Mol Physiol 1992 Nov; 263(5):L511-L518
• Contact Point Address:
  Andrew J. Ghio, Division of Allergy, Critical Care, and Respiratory Medicine, Department of Medicine, Duke University Medical Center, and the Department of Chemistry, Duke University, Durham, 27710
• CAS Registry Number:
  Crocidolite asbestos (CAS RN 12001-28-4) ; Iron (CAS RN 7439-89-6) ; Kaolinite (Al2(OH)4(Si2O5)) (CAS RN 1318-74-7) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Talc (Mg3H2(SiO3)4) (CAS RN 14807-96-6)
• Federal Fiscal Year:
  1993
• Performing Organization:
  University of Tenn Center Health Scien, Memphis, Tennessee
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  American Journal of Physiology: Lung Cellular and Molecular Physiology
• End Date:
  19900929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1d85e2b2b798b12a07fcd3638278f32df067ea7b3d7812f91c849c991863230c2b48a5246c95bc50039a66a4f2a31720b44c06748594b3e40342b3ae67914623
• Download URL:
  https://stacks.cdc.gov/view/cdc/205553/cdc_205553_DS1.pdf
• File Type:
  [PDF - 19.99 MB ]