Reproductive and developmental toxicity of N,N-diethyl-m-toluamide in rats

Details

• Personal Author:
  Chrislip DW ; Goad PW ; Hardin, Bryan D. ; Wright DM
• Description:
  The reproductive and developmental toxicity of N,N-diethyl-m- toluamide (134623) (DEET) was investigated in male and female Sprague-Dawley-rats. Pregnant dams were dosed by subcutaneous injection on gestational days six through 15 with DEET at 0.50, Only the 0.50ml/kg/day group had no deaths, and none of the rats in the 1.2ml/kg/day group survived. Pregnant dams were treated on gestational days six through 15 with 0.30ml/kg/day. Dams were either killed on gestational day 20 or allowed to deliver litters. There was no evidence of teratogenicity, embryotoxicity, or impaired perinatal survival following the dosing of pregnant rats with mutations, reduced fertility, or impaired perinatal survival of the offspring from male rats injected with 0.30 or 0.73ml/kg/day, 5 days a week for 9 weeks. Treated male and female rats showed signs of neurotoxicity, including a gait disturbance. While these findings did not support claims of potential reproductive or developmental toxicity following rat exposure to DEET, there were a number of incidental occurrences which suggest that neurotoxic responses may have occurred. The authors caution that under cases of extreme use some nervous system dysfunction may be found in humans exposed to this chemical. [Description provided by NIOSH]
• Subjects:
  Laboratories Nervous System Occupational Health Safety Teratogenesis Urogenital Diseases Urogenital System
• Keywords:
  Developmental-disorders Embryopathology Insect-repellents Laboratory-animals Neurotoxic-effects NIOSH-Author Reproductive-hazards Transplacental-exposure
• ISSN:
  0272-0590
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Ohio ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  33-42
• Volume:
  19
• Issue:
  1
• NIOSHTIC Number:
  nn:00208675
• Citation:
  Fundam Appl Toxicol 1992 Jul; 19(1):33-42
• CAS Registry Number:
  N,N-Diethyl-m-toluamide (CAS RN 134-62-3)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Peer Reviewed:
  True
• Source Full Name:
  Fundamental and Applied Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c43efd4c017bdb0e16b2d273c878021b8ecf466aabfa58a132bd1bca8eab8dde728f45ed87cf9c48ed0846de94537d44be5cb3308a91d8a5f001c9ea6a2cc95
• Download URL:
  https://stacks.cdc.gov/view/cdc/205492/cdc_205492_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]