Teratologic Assessment of Butylene Oxide, Styrene Oxide and Methyl Bromide

Details

• Personal Author:
  Cannon WC ; Carr DB ; Miller RA ; Montgomery LF ; Phelps DW ; Sikov MR
• Description:
  The teratogenicity of butylene-oxide (26249207), styrene-oxide (96093), and methylene-bromide (74953) was investigated. Pregnant Wistar-rats and New-Zealand-White-rabbits were exposed daily by inhalation to various low or high doses of the agents until gestation, day 21 for rats and 30 for rabbits; for some of the rats, exposures were started 3 weeks before mating. Fetuses were removed for examination after the final exposure. Butylene-oxide and methyl- bromide were not toxic to rats, but butylene-oxide and the high methylene-bromide doses were toxic to rabbits. Styrene-oxide was maternotoxic to both species. Teratogenic effects were seen only in rabbit or rat fetuses exposed to styrene-oxide. Preimplantation loss occurred in rats and resorptions were noted in rabbits. Fetal weight and length were reduced in both species. Rat fetuses also had ossification defects of the sternebrae and occipital bones. The authors conclude that styrene-oxide produces reproductive and developmental abnormalities. Methylene-bromide and butylene-oxide do not appear to be embryotoxic or teratogenic. [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Safety Teratogenesis Toxicology Urogenital System
• Keywords:
  Comparative-toxicology Congenital-effects Embryopathology Laboratory-animals NIOSH-Author Reproductive-effects
• Series:
  NIOSH Numbered Publications
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-76
• NIOSHTIC Number:
  nn:00117372
• NTIS Accession Number:
  PB81-168510
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 81-124, 1981 Jul; :1-76
• CAS Registry Number:
  Butylene oxide (CAS RN 26249-20-7) ; Dibromomethane (CAS RN 74-95-3) ; Styrene oxide (CAS RN 96-09-3)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c624b4fc034723dee332653fbdc4ec9a8eb226fa7f0c33da49694dd36fe9fbc0677656e59932e983cc36595e1b624ae3519586b44943d1c7f189442926e6a7b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/209419/cdc_209419_DS1.pdf
• File Type:
  [PDF - 7.46 MB ]