Pulmonary reactivity to vanadium pentoxide following subchronic inhalation exposure in a non-human primate animal model

Details

• Personal Author:
  Biagini, Raymond E. ; Boyle TJ ; Clark JC ; Hull, R. DeLon ; Knecht EA ; Lynch DW ; Moorman WJ ; Simon SD
• Description:
  The changes in pulmonary reactivity resulting from repeated vanadium- pentoxide (1314621) (V2O5) exposure were evaluated in monkeys. Adult, male cynomolgus-monkeys were exposed by inhalation for 6 hours/day, 5 days/week for 26 weeks to 0.1 to 1.1 milligram V2O5/cubic meter (mg/m3). One group was exposed to 0.1mg/m3 Monday, Wednesday, and Friday, and 1.1mg/m3 on Tuesday and Thursday. Another group was exposed to 0.5mg/m3, 5 days/week. Before exposure, challenge with V2O5 caused an impairment in pulmonary function. The airway obstruction was accompanied by a significant influx of inflammatory cells into the lung. Subchronic V2O5 inhalation did not produce an increase in V2O5 reactivity in comparison to the control group, and cytological, immunological and skin test results indicated the absence of allergic sensitization. A trend toward decreased pulmonary reactivity was found following subchronic V2O5 inhalation. Pulmonary reactivity to V2O5 was affected, as well as nonspecific reactivity to methacholine. The authors suggest that the absence of increased pulmonary reactivity to V2O5 following subchronic inhalation may be related to the induction of tolerance under the exposure conditions used in the study. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Hazardous Substances Inhalation Exposure Laboratories Occupational Health Respiratory System Respiratory Tract Diseases Safety Vanadium Compounds
• Keywords:
  Author Keywords: Vanadium Pentoxide Cynomolgus Monkeys Inhalants Inhalation-studies Laboratory-animals NIOSH-Author Organic-vapors Provocation Challenge Pulmonary Reactivity Respiratory-system-disorders Subchronic Inhalation Exposure Toxic-gases Vanadium-compounds

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• ISSN:
  0260-437X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  427-434
• Volume:
  12
• Issue:
  6
• NIOSHTIC Number:
  nn:00211573
• Citation:
  J Appl Toxicol 1992 Dec; 12(6):427-434
• Contact Point Address:
  Edwin A. Knecht, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health. 4676 Columbia Parkway. Cincinnati, OH 45226, USA
• CAS Registry Number:
  Vanadium oxide (V2O5) (CAS RN 1314-62-1)
• Federal Fiscal Year:
  1993
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Applied Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1d33e48321569719a6aef82495a93eeabf33dad918441142000cd69a976be44a088347799950f3442245395ba5fc6c45ff6cfb4ca95ca581e903e0da6375091a
• Download URL:
  https://stacks.cdc.gov/view/cdc/205437/cdc_205437_DS1.pdf
• File Type:
  [PDF - 894.16 KB ]