Peripheral markers of neurochemical function among workers exposed to styrene

Details

• Personal Author:
  Camp J ; Checkoway, Harvey ; Coccini T ; Costa LG ; Daniell WE ; Dills RL
• Description:
  A study of the ability of peripheral blood cell markers to serve as biomarkers for the effects of styrene (100425) on neurochemical function was conducted. The cohort consisted of 60 persons, 44 males, 20 to 47 years old, employed at three fiberglass reinforced plastics factories in western Washington State. They were exposed to styrene concentrations of 1 to 160 parts per million. The comparisons consisted of 18 machine assembly workers not exposed to styrene. Each subject completed a questionnaire to obtain information on work related central nervous system (CNS) symptoms, biodemographic characteristics, job history, smoking, and alcohol consumption. Peripheral blood samples were collected and analyzed for styrene and platelet monoamine-oxidase-type-B (MAOB) activity, lymphocyte sigma receptor binding, and serotonin uptake by platelets, which were used as markers of neurochemical function. Seventeen exposed subjects had blood styrene concentrations below concentrations of 0.05 to 0.19microg/ml, and 10 had blood styrene concentrations of 20microg/ml or greater. The prevalences of headache, dizziness, fatigue, irritation, memory loss, and feeling drunk were positively, significantly associated with blood styrene concentration. The degree of sigma receptor binding was not associated with blood styrene concentration. A weak positive association between platelet serotonin uptake and blood styrene concentration was observed. MAOB activity was strongly, inversely associated with blood styrene concentration. MAOB activity was also significantly, inversely associated with the prevalence of CNS symptoms. The authors conclude that MAOB activity may be a useful biomarker of styrene neurotoxicity. [Description provided by NIOSH]
• Subjects:
  Biochemistry Blood Enzymes Hematologic Tests Nervous System Occupational Exposure Occupational Health Plastics Polycyclic Aromatic Hydrocarbons Safety Solvents

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• Keywords:
  Aromatic-hydrocarbons Biochemical-indicators Blood-samples Enzyme-activity Neurotoxic-effects NIOSH-Grant NIOSH-Publication Occupational-exposure Organic-solvents Plastics-industry Reinforced-plastics

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• ISSN:
  0007-1072
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  49
• Issue:
  8
• NIOSHTIC Number:
  nn:00209310
• Citation:
  Br J Ind Med 1992 Aug; 49(8):560-565
• Contact Point Address:
  Environmental Health University of Washington Dept/environmental Hlth/sc-34 Seattle, WA 98195
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19881201
• Source Full Name:
  British Journal of Industrial Medicine
• End Date:
  19921130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f0b26ce0018864d0886a7163580fa48c5dc820075e72db9cd405e252a3db6a9096d9cbbd65848e488b9961e0d419a079b82f874487416d8f4613d26ecbc62d0
• Download URL:
  https://stacks.cdc.gov/view/cdc/205348/cdc_205348_DS1.pdf
• File Type:
  [PDF - 1013.21 KB ]